Breast physiology: Normal and abnormal development and function

Susie X. Sun; Zeynep Bostanci; Rena B. Kass; Anne T. Mancino; Arlan L. Rosenbloom; V. Suzanne Klimberg; Kirby I. Bland

doi:10.1016/B978-0-323-35955-9.00003-9

Breast physiology: Normal and abnormal development and function

Susie X. Sun, Zeynep Bostanci, Rena B. Kass, Anne T. Mancino, Arlan L. Rosenbloom, V. Suzanne Klimberg, Kirby I. Bland

Research output: Chapter in Book/Report/Conference proceeding › Chapter

10 Scopus citations

Abstract

The mammary gland is composed of an epithelial system of ducts and lobuloalveolar secretory units embedded in a mesenchymally derived fat pad. The growth and morphogenesis of the epithelial structures of the breast occur in various stages and are associated with concurrent hormonal changes and affected by genetic mutations. Each stage reflects the effects of systemic hormones on the glandular epithelium as well as the paracrine effects of locally derived growth factors and other regulatory products produced in the stroma. Appreciating the relationship of epithelium to mesenchyme in normal growth is essential for understanding developmental abnormalities and factors that may lead to disease.

Original language	English (US)
Title of host publication	The Breast
Subtitle of host publication	Comprehensive Management of Benign and Malignant Diseases
Publisher	Elsevier Inc.
Pages	37-56.e6
ISBN (Print)	9780323359559
DOIs	https://doi.org/10.1016/B978-0-323-35955-9.00003-9
State	Published - 2018

Keywords

Breast physiology
Development
Embryology
Lactation
Mammary gland
Menopause
Menstruation
Pregnancy
Puberty

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-35955-9.00003-9

Cite this

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title = "Breast physiology: Normal and abnormal development and function",

abstract = "The mammary gland is composed of an epithelial system of ducts and lobuloalveolar secretory units embedded in a mesenchymally derived fat pad. The growth and morphogenesis of the epithelial structures of the breast occur in various stages and are associated with concurrent hormonal changes and affected by genetic mutations. Each stage reflects the effects of systemic hormones on the glandular epithelium as well as the paracrine effects of locally derived growth factors and other regulatory products produced in the stroma. Appreciating the relationship of epithelium to mesenchyme in normal growth is essential for understanding developmental abnormalities and factors that may lead to disease.",

keywords = "Breast physiology, Development, Embryology, Lactation, Mammary gland, Menopause, Menstruation, Pregnancy, Puberty",

author = "Sun, {Susie X.} and Zeynep Bostanci and Kass, {Rena B.} and Mancino, {Anne T.} and Rosenbloom, {Arlan L.} and Klimberg, {V. Suzanne} and Bland, {Kirby I.}",

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T2 - Normal and abnormal development and function

AU - Sun, Susie X.

AU - Bostanci, Zeynep

AU - Kass, Rena B.

AU - Mancino, Anne T.

AU - Rosenbloom, Arlan L.

AU - Klimberg, V. Suzanne

AU - Bland, Kirby I.

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AB - The mammary gland is composed of an epithelial system of ducts and lobuloalveolar secretory units embedded in a mesenchymally derived fat pad. The growth and morphogenesis of the epithelial structures of the breast occur in various stages and are associated with concurrent hormonal changes and affected by genetic mutations. Each stage reflects the effects of systemic hormones on the glandular epithelium as well as the paracrine effects of locally derived growth factors and other regulatory products produced in the stroma. Appreciating the relationship of epithelium to mesenchyme in normal growth is essential for understanding developmental abnormalities and factors that may lead to disease.

KW - Breast physiology

KW - Development

KW - Embryology

KW - Lactation

KW - Mammary gland

KW - Menopause

KW - Menstruation

KW - Pregnancy

KW - Puberty

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BT - The Breast

PB - Elsevier Inc.

ER -

Breast physiology: Normal and abnormal development and function

Abstract

Keywords

ASJC Scopus subject areas

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