Breathing frequency responses to pulmonary CO 2 in an isolated lobe of the canine lung

J. O. Nilsestuen, R. L. Coon, F. O. Igler, E. J. Zuperku, J. P. Kampine

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Recent studies have indicated that the breathing frequency responses to inspired CO 2 in part result from changes in pulmonary stretch receptor activity. Pulmonary CO 2 may alter frequency by direct inhibition of stretch receptor discharge, or secondarily, by changes in airway mechanics. The vascularly isolated left lower lobe (LLL) of the canine lung was used to determine the effect of hypocapnic airway constriction on the pulmonary CO 2 reflex. The upper and middle lobes of the left lung were removed and the right vagus nerve sectioned. Blood was recirculated through the LLL. Diaphragm electromyogram was used as an index of respiratory center activity and to trigger ventilation of the left lower lobe. Lobar hypocapnia increased peak airway pressure and reduced respiratory rate. However, infusion of isoproterenol or the use of a mechanical overflow system to block the airway pressure response prevented the frequency changes associated with CO 2. Although both the direct and mechanical effects of CO 2 on stretch receptors may contribute to the reflex, in the LLL preparation the mechanical effects predominate.

    Original languageEnglish (US)
    Pages (from-to)1201-1206
    Number of pages6
    JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
    Volume47
    Issue number6
    StatePublished - 1979

    Fingerprint

    Carbon Monoxide
    Canidae
    Respiration
    Lung
    Mechanoreceptors
    Reflex
    Pulmonary Stretch Receptors
    Respiratory Center
    Hypocapnia
    Pressure
    Vagus Nerve
    Electromyography
    Respiratory Rate
    Diaphragm
    Mechanics
    Isoproterenol
    Constriction
    Ventilation

    ASJC Scopus subject areas

    • Physiology
    • Endocrinology

    Cite this

    Breathing frequency responses to pulmonary CO 2 in an isolated lobe of the canine lung. / Nilsestuen, J. O.; Coon, R. L.; Igler, F. O.; Zuperku, E. J.; Kampine, J. P.

    In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 47, No. 6, 1979, p. 1201-1206.

    Research output: Contribution to journalArticle

    Nilsestuen, J. O. ; Coon, R. L. ; Igler, F. O. ; Zuperku, E. J. ; Kampine, J. P. / Breathing frequency responses to pulmonary CO 2 in an isolated lobe of the canine lung. In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 1979 ; Vol. 47, No. 6. pp. 1201-1206.
    @article{08caec237da84612897a0e291f5b3f2e,
    title = "Breathing frequency responses to pulmonary CO 2 in an isolated lobe of the canine lung",
    abstract = "Recent studies have indicated that the breathing frequency responses to inspired CO 2 in part result from changes in pulmonary stretch receptor activity. Pulmonary CO 2 may alter frequency by direct inhibition of stretch receptor discharge, or secondarily, by changes in airway mechanics. The vascularly isolated left lower lobe (LLL) of the canine lung was used to determine the effect of hypocapnic airway constriction on the pulmonary CO 2 reflex. The upper and middle lobes of the left lung were removed and the right vagus nerve sectioned. Blood was recirculated through the LLL. Diaphragm electromyogram was used as an index of respiratory center activity and to trigger ventilation of the left lower lobe. Lobar hypocapnia increased peak airway pressure and reduced respiratory rate. However, infusion of isoproterenol or the use of a mechanical overflow system to block the airway pressure response prevented the frequency changes associated with CO 2. Although both the direct and mechanical effects of CO 2 on stretch receptors may contribute to the reflex, in the LLL preparation the mechanical effects predominate.",
    author = "Nilsestuen, {J. O.} and Coon, {R. L.} and Igler, {F. O.} and Zuperku, {E. J.} and Kampine, {J. P.}",
    year = "1979",
    language = "English (US)",
    volume = "47",
    pages = "1201--1206",
    journal = "Journal of Applied Physiology",
    issn = "8750-7587",
    publisher = "American Physiological Society",
    number = "6",

    }

    TY - JOUR

    T1 - Breathing frequency responses to pulmonary CO 2 in an isolated lobe of the canine lung

    AU - Nilsestuen, J. O.

    AU - Coon, R. L.

    AU - Igler, F. O.

    AU - Zuperku, E. J.

    AU - Kampine, J. P.

    PY - 1979

    Y1 - 1979

    N2 - Recent studies have indicated that the breathing frequency responses to inspired CO 2 in part result from changes in pulmonary stretch receptor activity. Pulmonary CO 2 may alter frequency by direct inhibition of stretch receptor discharge, or secondarily, by changes in airway mechanics. The vascularly isolated left lower lobe (LLL) of the canine lung was used to determine the effect of hypocapnic airway constriction on the pulmonary CO 2 reflex. The upper and middle lobes of the left lung were removed and the right vagus nerve sectioned. Blood was recirculated through the LLL. Diaphragm electromyogram was used as an index of respiratory center activity and to trigger ventilation of the left lower lobe. Lobar hypocapnia increased peak airway pressure and reduced respiratory rate. However, infusion of isoproterenol or the use of a mechanical overflow system to block the airway pressure response prevented the frequency changes associated with CO 2. Although both the direct and mechanical effects of CO 2 on stretch receptors may contribute to the reflex, in the LLL preparation the mechanical effects predominate.

    AB - Recent studies have indicated that the breathing frequency responses to inspired CO 2 in part result from changes in pulmonary stretch receptor activity. Pulmonary CO 2 may alter frequency by direct inhibition of stretch receptor discharge, or secondarily, by changes in airway mechanics. The vascularly isolated left lower lobe (LLL) of the canine lung was used to determine the effect of hypocapnic airway constriction on the pulmonary CO 2 reflex. The upper and middle lobes of the left lung were removed and the right vagus nerve sectioned. Blood was recirculated through the LLL. Diaphragm electromyogram was used as an index of respiratory center activity and to trigger ventilation of the left lower lobe. Lobar hypocapnia increased peak airway pressure and reduced respiratory rate. However, infusion of isoproterenol or the use of a mechanical overflow system to block the airway pressure response prevented the frequency changes associated with CO 2. Although both the direct and mechanical effects of CO 2 on stretch receptors may contribute to the reflex, in the LLL preparation the mechanical effects predominate.

    UR - http://www.scopus.com/inward/record.url?scp=0018577317&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0018577317&partnerID=8YFLogxK

    M3 - Article

    VL - 47

    SP - 1201

    EP - 1206

    JO - Journal of Applied Physiology

    JF - Journal of Applied Physiology

    SN - 8750-7587

    IS - 6

    ER -