Brief report

Impact of option B+ on the infant PMTCT cascade in Lilongwe, Malawi

Maria H. Kim, Saeed Ahmed, Mina C. Hosseinipour, Xiaoying Yu, Chi Nguyen, Frank Chimbwandira, Mary E. Paul, Peter N. Kazembe, Elaine J. Abrams

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This observational study compared uptake of infant prevention of mother-to-child transmission of HIV services pre/post implementation of Option B+ in Lilongwe, Malawi. There were 845 (pre) and 998 (post) births. Post-B+, infants had longer median predelivery maternal antiretroviral therapy {62 days [interquartile range (IQR): 38-94] pre-B+ vs. 95 days [IQR: 61-131] post-B+; P < 0.0001} and improved polymerase chain reaction testing (82.0% vs. 86.5%; P 0.01) at younger median age [7.6 weeks (IQR: 6.6-10.9) vs. 6.9 (IQR: 6.4-8.1); P < 0.0001]. Proportion testing polymerase chain reaction positive decreased (4.6% vs. 2.6%; P 0.03). Proportion of HIV-infected infants starting antiretroviral therapy (75% vs. 77.3%) and age at initiation [19.7 weeks (IQR: 15.4-31.1) vs. 16 (IQR: 13.3-17.9)] remained unchanged. These findings suggest modest improvements in infant care with Option B+.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume70
Issue number1
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Fingerprint

Malawi
Mothers
HIV
Infant Care
Polymerase Chain Reaction
Observational Studies
Parturition
Therapeutics

Keywords

  • Africa
  • antiretroviral
  • early infant diagnosis
  • HIV
  • Malawi
  • Option B+
  • PMTCT

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Brief report : Impact of option B+ on the infant PMTCT cascade in Lilongwe, Malawi. / Kim, Maria H.; Ahmed, Saeed; Hosseinipour, Mina C.; Yu, Xiaoying; Nguyen, Chi; Chimbwandira, Frank; Paul, Mary E.; Kazembe, Peter N.; Abrams, Elaine J.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 70, No. 1, 01.09.2015, p. 99-103.

Research output: Contribution to journalArticle

Kim, MH, Ahmed, S, Hosseinipour, MC, Yu, X, Nguyen, C, Chimbwandira, F, Paul, ME, Kazembe, PN & Abrams, EJ 2015, 'Brief report: Impact of option B+ on the infant PMTCT cascade in Lilongwe, Malawi', Journal of Acquired Immune Deficiency Syndromes, vol. 70, no. 1, pp. 99-103. https://doi.org/10.1097/QAI.0000000000000692
Kim, Maria H. ; Ahmed, Saeed ; Hosseinipour, Mina C. ; Yu, Xiaoying ; Nguyen, Chi ; Chimbwandira, Frank ; Paul, Mary E. ; Kazembe, Peter N. ; Abrams, Elaine J. / Brief report : Impact of option B+ on the infant PMTCT cascade in Lilongwe, Malawi. In: Journal of Acquired Immune Deficiency Syndromes. 2015 ; Vol. 70, No. 1. pp. 99-103.
@article{f363a87d7ed64b0da5d200819074e4e7,
title = "Brief report: Impact of option B+ on the infant PMTCT cascade in Lilongwe, Malawi",
abstract = "This observational study compared uptake of infant prevention of mother-to-child transmission of HIV services pre/post implementation of Option B+ in Lilongwe, Malawi. There were 845 (pre) and 998 (post) births. Post-B+, infants had longer median predelivery maternal antiretroviral therapy {62 days [interquartile range (IQR): 38-94] pre-B+ vs. 95 days [IQR: 61-131] post-B+; P < 0.0001} and improved polymerase chain reaction testing (82.0{\%} vs. 86.5{\%}; P 0.01) at younger median age [7.6 weeks (IQR: 6.6-10.9) vs. 6.9 (IQR: 6.4-8.1); P < 0.0001]. Proportion testing polymerase chain reaction positive decreased (4.6{\%} vs. 2.6{\%}; P 0.03). Proportion of HIV-infected infants starting antiretroviral therapy (75{\%} vs. 77.3{\%}) and age at initiation [19.7 weeks (IQR: 15.4-31.1) vs. 16 (IQR: 13.3-17.9)] remained unchanged. These findings suggest modest improvements in infant care with Option B+.",
keywords = "Africa, antiretroviral, early infant diagnosis, HIV, Malawi, Option B+, PMTCT",
author = "Kim, {Maria H.} and Saeed Ahmed and Hosseinipour, {Mina C.} and Xiaoying Yu and Chi Nguyen and Frank Chimbwandira and Paul, {Mary E.} and Kazembe, {Peter N.} and Abrams, {Elaine J.}",
year = "2015",
month = "9",
day = "1",
doi = "10.1097/QAI.0000000000000692",
language = "English (US)",
volume = "70",
pages = "99--103",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Brief report

T2 - Impact of option B+ on the infant PMTCT cascade in Lilongwe, Malawi

AU - Kim, Maria H.

AU - Ahmed, Saeed

AU - Hosseinipour, Mina C.

AU - Yu, Xiaoying

AU - Nguyen, Chi

AU - Chimbwandira, Frank

AU - Paul, Mary E.

AU - Kazembe, Peter N.

AU - Abrams, Elaine J.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - This observational study compared uptake of infant prevention of mother-to-child transmission of HIV services pre/post implementation of Option B+ in Lilongwe, Malawi. There were 845 (pre) and 998 (post) births. Post-B+, infants had longer median predelivery maternal antiretroviral therapy {62 days [interquartile range (IQR): 38-94] pre-B+ vs. 95 days [IQR: 61-131] post-B+; P < 0.0001} and improved polymerase chain reaction testing (82.0% vs. 86.5%; P 0.01) at younger median age [7.6 weeks (IQR: 6.6-10.9) vs. 6.9 (IQR: 6.4-8.1); P < 0.0001]. Proportion testing polymerase chain reaction positive decreased (4.6% vs. 2.6%; P 0.03). Proportion of HIV-infected infants starting antiretroviral therapy (75% vs. 77.3%) and age at initiation [19.7 weeks (IQR: 15.4-31.1) vs. 16 (IQR: 13.3-17.9)] remained unchanged. These findings suggest modest improvements in infant care with Option B+.

AB - This observational study compared uptake of infant prevention of mother-to-child transmission of HIV services pre/post implementation of Option B+ in Lilongwe, Malawi. There were 845 (pre) and 998 (post) births. Post-B+, infants had longer median predelivery maternal antiretroviral therapy {62 days [interquartile range (IQR): 38-94] pre-B+ vs. 95 days [IQR: 61-131] post-B+; P < 0.0001} and improved polymerase chain reaction testing (82.0% vs. 86.5%; P 0.01) at younger median age [7.6 weeks (IQR: 6.6-10.9) vs. 6.9 (IQR: 6.4-8.1); P < 0.0001]. Proportion testing polymerase chain reaction positive decreased (4.6% vs. 2.6%; P 0.03). Proportion of HIV-infected infants starting antiretroviral therapy (75% vs. 77.3%) and age at initiation [19.7 weeks (IQR: 15.4-31.1) vs. 16 (IQR: 13.3-17.9)] remained unchanged. These findings suggest modest improvements in infant care with Option B+.

KW - Africa

KW - antiretroviral

KW - early infant diagnosis

KW - HIV

KW - Malawi

KW - Option B+

KW - PMTCT

UR - http://www.scopus.com/inward/record.url?scp=84939780346&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939780346&partnerID=8YFLogxK

U2 - 10.1097/QAI.0000000000000692

DO - 10.1097/QAI.0000000000000692

M3 - Article

VL - 70

SP - 99

EP - 103

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 1

ER -