Brief report: Impact of option B+ on the infant PMTCT cascade in Lilongwe, Malawi

Maria H. Kim, Saeed Ahmed, Mina C. Hosseinipour, Xiaoying Yu, Chi Nguyen, Frank Chimbwandira, Mary E. Paul, Peter N. Kazembe, Elaine J. Abrams

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

This observational study compared uptake of infant prevention of mother-to-child transmission of HIV services pre/post implementation of Option B+ in Lilongwe, Malawi. There were 845 (pre) and 998 (post) births. Post-B+, infants had longer median predelivery maternal antiretroviral therapy {62 days [interquartile range (IQR): 38-94] pre-B+ vs. 95 days [IQR: 61-131] post-B+; P < 0.0001} and improved polymerase chain reaction testing (82.0% vs. 86.5%; P 0.01) at younger median age [7.6 weeks (IQR: 6.6-10.9) vs. 6.9 (IQR: 6.4-8.1); P < 0.0001]. Proportion testing polymerase chain reaction positive decreased (4.6% vs. 2.6%; P 0.03). Proportion of HIV-infected infants starting antiretroviral therapy (75% vs. 77.3%) and age at initiation [19.7 weeks (IQR: 15.4-31.1) vs. 16 (IQR: 13.3-17.9)] remained unchanged. These findings suggest modest improvements in infant care with Option B+.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume70
Issue number1
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Keywords

  • Africa
  • antiretroviral
  • early infant diagnosis
  • HIV
  • Malawi
  • Option B+
  • PMTCT

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Kim, M. H., Ahmed, S., Hosseinipour, M. C., Yu, X., Nguyen, C., Chimbwandira, F., Paul, M. E., Kazembe, P. N., & Abrams, E. J. (2015). Brief report: Impact of option B+ on the infant PMTCT cascade in Lilongwe, Malawi. Journal of Acquired Immune Deficiency Syndromes, 70(1), 99-103. https://doi.org/10.1097/QAI.0000000000000692