Broad-spectrum agents for flaviviral infections: Dengue, Zika and beyond

Veaceslav Boldescu, Mira A.M. Behnam, Nikos Vasilakis, Christian D. Klein

Research output: Contribution to journalReview article

98 Scopus citations

Abstract

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum activity is particularly desirable to prepare for the next flaviviral epidemic, which could emerge from as-yet unknown or neglected viruses. Potential molecular targets for broad-spectrum antiflaviviral compounds include viral proteins, such as the viral protease or polymerase, and host targets that are exploited by these viruses during entry and replication, including α-glucosidase and proteins involved in nucleoside biosynthesis. Numerous compounds with broad-spectrum antiviral activity have already been identified by target-specific or phenotypic assays. For other compounds, broad-spectrum activity can be anticipated because of their mode of action and molecular targets.

Original languageEnglish (US)
Pages (from-to)565-586
Number of pages22
JournalNature Reviews Drug Discovery
Volume16
Issue number8
DOIs
StatePublished - Jul 31 2017

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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