@article{45834e50f84a42f0ad2b0f87239fbd68,
title = "Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans",
abstract = "Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.",
author = "Maria Chondronikola and Elena Volpi and Elisabet B{\o}rsheim and Craig Porter and Saraf, {Manish K.} and Palam Annamalai and Christina Yfanti and Tony Chao and Daniel Wong and Kosaku Shinoda and Labbe, {Sebastien M.} and Hurren, {Nicholas M.} and Fernando Cesani and Shingo Kajimura and Labros Sidossis",
note = "Funding Information: This study was conducted with the support of the Institute for Translational Sciences at the University of Texas Medical Branch and supported in part by a Clinical and Translational Science Award (UL1TR000071) from the National Center for Advancing Translational Sciences, National Institutes of Health, the American Diabetes Association (1-14-TS-35 to L.S.S.), Shriners Hospitals for Children grants (84090 and 85310 to L.S.S.), the John Sealy Memorial Endowment Fund for Biomedical Research (66992 to L.S.S.), the Claude Pepper Older Americans Independence Center (P30 AG024832 to E.V.), the Sealy Center on Aging (grant to L.S.S.), and the NIH DK97441 to S.K. M.C. was funded by the Onassis Foundation. S.M.L. was funded by a Canadian Institute of Health Research postdoctoral fellowship. C.P. was supported in part by a National Institute of Disability and Rehabilitation Research Postdoctoral Training Grant (H133P110012). Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
month = jun,
day = "14",
doi = "10.1016/j.cmet.2016.04.029",
language = "English (US)",
volume = "23",
pages = "1200--1206",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",
}