Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

Maria Chondronikola; Elena Volpi; Elisabet Børsheim; Craig Porter; Manish K. Saraf; Palam Annamalai; Christina Yfanti; Tony Chao; Daniel Wong; Kosaku Shinoda; Sebastien M. Labbe; Nicholas M. Hurren; Fernardo Cesani; Shingo Kajimura; Labros S. Sidossis

doi:10.1016/j.cmet.2016.04.029

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

Maria Chondronikola, Elena Volpi, Elisabet Børsheim, Craig Porter, Manish K. Saraf, Palam Annamalai, Christina Yfanti, Tony Chao, Daniel Wong, Kosaku Shinoda, Sebastien M. Labbe, Nicholas M. Hurren, Fernardo Cesani, Shingo Kajimura, Labros S. Sidossis

Research output: Contribution to journal › Article › peer-review

263 Scopus citations

Abstract

Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.

Original language	English (US)
Pages (from-to)	1200-1206
Number of pages	7
Journal	Cell Metabolism
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2016.04.029
State	Published - Jun 14 2016

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1016/j.cmet.2016.04.029

Cite this

Chondronikola, M., Volpi, E., Børsheim, E., Porter, C., Saraf, M. K., Annamalai, P., Yfanti, C., Chao, T., Wong, D., Shinoda, K., Labbe, S. M., Hurren, N. M., Cesani, F., Kajimura, S., & Sidossis, L. S. (2016). Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. Cell Metabolism, 23(6), 1200-1206. https://doi.org/10.1016/j.cmet.2016.04.029

Chondronikola, M, Volpi, E, Børsheim, E, Porter, C, Saraf, MK, Annamalai, P, Yfanti, C, Chao, T, Wong, D, Shinoda, K, Labbe, SM, Hurren, NM, Cesani, F, Kajimura, S & Sidossis, LS 2016, 'Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans', Cell Metabolism, vol. 23, no. 6, pp. 1200-1206. https://doi.org/10.1016/j.cmet.2016.04.029

@article{45834e50f84a42f0ad2b0f87239fbd68,

title = "Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans",

abstract = "Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.",

author = "Maria Chondronikola and Elena Volpi and Elisabet B{\o}rsheim and Craig Porter and Saraf, {Manish K.} and Palam Annamalai and Christina Yfanti and Tony Chao and Daniel Wong and Kosaku Shinoda and Labbe, {Sebastien M.} and Hurren, {Nicholas M.} and Fernardo Cesani and Shingo Kajimura and Sidossis, {Labros S.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = jun,

day = "14",

doi = "10.1016/j.cmet.2016.04.029",

language = "English (US)",

volume = "23",

pages = "1200--1206",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

AU - Chondronikola, Maria

AU - Volpi, Elena

AU - Børsheim, Elisabet

AU - Porter, Craig

AU - Saraf, Manish K.

AU - Annamalai, Palam

AU - Yfanti, Christina

AU - Chao, Tony

AU - Wong, Daniel

AU - Shinoda, Kosaku

AU - Labbe, Sebastien M.

AU - Hurren, Nicholas M.

AU - Cesani, Fernardo

AU - Kajimura, Shingo

AU - Sidossis, Labros S.

PY - 2016/6/14

Y1 - 2016/6/14

N2 - Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.

AB - Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.

UR - http://www.scopus.com/inward/record.url?scp=84969939788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969939788&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2016.04.029

DO - 10.1016/j.cmet.2016.04.029

M3 - Article

C2 - 27238638

AN - SCOPUS:84969939788

SN - 1550-4131

VL - 23

SP - 1200

EP - 1206

JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

ER -

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this