Brown and beige fat in humans: Thermogenic adipocytes that control energy and glucose homeostasis

Labros Sidossis, Shingo Kajimura

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

Brown adipose tissue (BAT), a specialized fat that dissipates energy to produce heat, plays an important role in the regulation of energy balance. Two types of thermogenic adipocytes with distinct developmental and anatomical features exist in rodents and humans: classical brown adipocytes and beige (also referred to as brite) adipocytes. While classical brown adipocytes are located mainly in dedicated BAT depots of rodents and infants, beige adipocytes sporadically reside with white adipocytes and emerge in response to certain environmental cues, such as chronic cold exposure, a process often referred to as "browning" of white adipose tissue. Recent studies indicate the existence of beige adipocytes in adult humans, making this cell type an attractive therapeutic target for obesity and obesity-related diseases, including type 2 diabetes. This Review aims to cover recent progress in our understanding of the anatomical, developmental, and functional characteristics of brown and beige adipocytes and discuss emerging questions, with a special emphasis on adult human BAT.

Original languageEnglish (US)
Pages (from-to)478-486
Number of pages9
JournalJournal of Clinical Investigation
Volume125
Issue number2
DOIs
StatePublished - Feb 2 2015
Externally publishedYes

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Brown Adipose Tissue
Brown Adipocytes
Adipocytes
Homeostasis
Glucose
Rodentia
Obesity
White Adipocytes
White Adipose Tissue
Type 2 Diabetes Mellitus
Cues
Hot Temperature
Fats
Beige Adipocytes
Beige Adipose Tissue
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Brown and beige fat in humans : Thermogenic adipocytes that control energy and glucose homeostasis. / Sidossis, Labros; Kajimura, Shingo.

In: Journal of Clinical Investigation, Vol. 125, No. 2, 02.02.2015, p. 478-486.

Research output: Contribution to journalArticle

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