Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

Labros S. Sidossis, Craig Porter, Manish K. Saraf, Elisabet Børsheim, Ravi Radhakrishnan, Tony Chao, Arham Ali, Maria Chondronikola, Ronald Mlcak, Celeste Finnerty, Hal K. Hawkins, Tracy Toliver-Kinsky, David Herndon

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has become a therapeutic target for obesity and insulin resistance. We examined whether human subcutaneous white adipose tissue (sWAT) can adopt a BAT-like phenotype using a clinical model of prolonged and severe adrenergic stress. sWAT samples were collected from severely burned and healthy individuals. A subset of burn victims were prospectively followed during their acute hospitalization. Browning of sWAT was determined by the presence of multilocular adipocytes, uncoupling protein 1 (UCP1), and increased mitochondrial density and respiratory capacity. Multilocular UCP1-positive adipocytes were found in sWAT samples from burn patients. UCP1 mRNA, mitochondrial density, and leak respiratory capacity in sWAT increased after burn trauma. Our data demonstrate that human sWAT can transform from an energy-storing to an energy-dissipating tissue, which opens new research avenues in our quest to prevent and treat obesity and its metabolic complications.

Original languageEnglish (US)
Pages (from-to)219-227
Number of pages9
JournalCell Metabolism
Volume22
Issue number2
DOIs
StatePublished - Aug 4 2015

Fingerprint

White Adipose Tissue
Subcutaneous Fat
Adrenergic Agents
Brown Adipose Tissue
Adipocytes
Obesity
Insulin Resistance
Hospitalization
Phenotype
Wounds and Injuries
Research
Uncoupling Protein 1

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Sidossis, L. S., Porter, C., Saraf, M. K., Børsheim, E., Radhakrishnan, R., Chao, T., ... Herndon, D. (2015). Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress. Cell Metabolism, 22(2), 219-227. https://doi.org/10.1016/j.cmet.2015.06.022

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress. / Sidossis, Labros S.; Porter, Craig; Saraf, Manish K.; Børsheim, Elisabet; Radhakrishnan, Ravi; Chao, Tony; Ali, Arham; Chondronikola, Maria; Mlcak, Ronald; Finnerty, Celeste; Hawkins, Hal K.; Toliver-Kinsky, Tracy; Herndon, David.

In: Cell Metabolism, Vol. 22, No. 2, 04.08.2015, p. 219-227.

Research output: Contribution to journalArticle

Sidossis, LS, Porter, C, Saraf, MK, Børsheim, E, Radhakrishnan, R, Chao, T, Ali, A, Chondronikola, M, Mlcak, R, Finnerty, C, Hawkins, HK, Toliver-Kinsky, T & Herndon, D 2015, 'Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress', Cell Metabolism, vol. 22, no. 2, pp. 219-227. https://doi.org/10.1016/j.cmet.2015.06.022
Sidossis, Labros S. ; Porter, Craig ; Saraf, Manish K. ; Børsheim, Elisabet ; Radhakrishnan, Ravi ; Chao, Tony ; Ali, Arham ; Chondronikola, Maria ; Mlcak, Ronald ; Finnerty, Celeste ; Hawkins, Hal K. ; Toliver-Kinsky, Tracy ; Herndon, David. / Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress. In: Cell Metabolism. 2015 ; Vol. 22, No. 2. pp. 219-227.
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