Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

Labros S. Sidossis, Craig Porter, Manish K. Saraf, Elisabet Børsheim, Ravi S. Radhakrishnan, Tony Chao, Arham Ali, Maria Chondronikola, Ronald Mlcak, Celeste C. Finnerty, Hal K. Hawkins, Tracy Toliver-Kinsky, David N. Herndon

Research output: Contribution to journalArticle

182 Scopus citations

Abstract

Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has become a therapeutic target for obesity and insulin resistance. We examined whether human subcutaneous white adipose tissue (sWAT) can adopt a BAT-like phenotype using a clinical model of prolonged and severe adrenergic stress. sWAT samples were collected from severely burned and healthy individuals. A subset of burn victims were prospectively followed during their acute hospitalization. Browning of sWAT was determined by the presence of multilocular adipocytes, uncoupling protein 1 (UCP1), and increased mitochondrial density and respiratory capacity. Multilocular UCP1-positive adipocytes were found in sWAT samples from burn patients. UCP1 mRNA, mitochondrial density, and leak respiratory capacity in sWAT increased after burn trauma. Our data demonstrate that human sWAT can transform from an energy-storing to an energy-dissipating tissue, which opens new research avenues in our quest to prevent and treat obesity and its metabolic complications.

Original languageEnglish (US)
Pages (from-to)219-227
Number of pages9
JournalCell Metabolism
Volume22
Issue number2
DOIs
StatePublished - Aug 4 2015

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress'. Together they form a unique fingerprint.

  • Cite this

    Sidossis, L. S., Porter, C., Saraf, M. K., Børsheim, E., Radhakrishnan, R. S., Chao, T., Ali, A., Chondronikola, M., Mlcak, R., Finnerty, C. C., Hawkins, H. K., Toliver-Kinsky, T., & Herndon, D. N. (2015). Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress. Cell Metabolism, 22(2), 219-227. https://doi.org/10.1016/j.cmet.2015.06.022