Bubble formation during pulsed laser ablation: mechanism and implications

Ton G. Leeuwen, E. D. Jansen, Massoud Motamedi, Ashley J. Welch, Cornelius M D Borst

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Holmium (λ = 2.09 μm) and excimer (λ = 308 nm) lasers are used for ablation of tissue. In a previous study it was demonstrated that both excimer and holmium laser pulses produce fast expanding and collapsing vapor bubbles. To investigate whether the excimer induced bubble is caused by vaporization of water, the threshold fluence for bubble formation at a bare fiber tip in water was compared between the excimer laser (pulse length 115 ns) and the Q-switched and free-running holmium lasers (pulse length 1 μs to 250 μs, respectively). To induce bubble formation by excimer laser light in water, the absorber oxybuprocaine-hydrochloride (OBP-HCl) was added to the water. Fast flash photography was used to measure the threshold fluence as a function of the water temperature (6 - 90°C) at environmental pressure. The ultraviolet excimer laser light is strongly absorbed by blood. Therefore, to document the implications of bubble formation at fluences above the tissue ablation threshold, excimer laser pulses were delivered in vitro in hemoglobin solution and in vivo in the femoral artery of the rabbit. We conclude that the principal content of the fast bubble induced by a 308 nm excimer laser pulse is water vapor. Therefore, delivery of excimer laser pulses in a water or blood environment will cause fast expanding water vapor bubbles, which may induce mechanical damage to adjacent tissue.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Place of PublicationBellingham, WA, United States
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages13-22
Number of pages10
Volume1882
ISBN (Print)0819411094
StatePublished - 1993
Externally publishedYes
EventLaser-Tissue Interaction IV - Los Angeles, CA, USA
Duration: Jan 18 1993Jan 20 1993

Other

OtherLaser-Tissue Interaction IV
CityLos Angeles, CA, USA
Period1/18/931/20/93

Fingerprint

Bubble formation
Excimer lasers
Laser ablation
Pulsed lasers
excimer lasers
laser ablation
Laser pulses
pulsed lasers
bubbles
Holmium
holmium
pulses
Water
fluence
Tissue
Ablation
water
Water vapor
excimers
Blood

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Leeuwen, T. G., Jansen, E. D., Motamedi, M., Welch, A. J., & Borst, C. M. D. (1993). Bubble formation during pulsed laser ablation: mechanism and implications. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1882, pp. 13-22). Bellingham, WA, United States: Publ by Society of Photo-Optical Instrumentation Engineers.

Bubble formation during pulsed laser ablation : mechanism and implications. / Leeuwen, Ton G.; Jansen, E. D.; Motamedi, Massoud; Welch, Ashley J.; Borst, Cornelius M D.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1882 Bellingham, WA, United States : Publ by Society of Photo-Optical Instrumentation Engineers, 1993. p. 13-22.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Leeuwen, TG, Jansen, ED, Motamedi, M, Welch, AJ & Borst, CMD 1993, Bubble formation during pulsed laser ablation: mechanism and implications. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 1882, Publ by Society of Photo-Optical Instrumentation Engineers, Bellingham, WA, United States, pp. 13-22, Laser-Tissue Interaction IV, Los Angeles, CA, USA, 1/18/93.
Leeuwen TG, Jansen ED, Motamedi M, Welch AJ, Borst CMD. Bubble formation during pulsed laser ablation: mechanism and implications. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1882. Bellingham, WA, United States: Publ by Society of Photo-Optical Instrumentation Engineers. 1993. p. 13-22
Leeuwen, Ton G. ; Jansen, E. D. ; Motamedi, Massoud ; Welch, Ashley J. ; Borst, Cornelius M D. / Bubble formation during pulsed laser ablation : mechanism and implications. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1882 Bellingham, WA, United States : Publ by Society of Photo-Optical Instrumentation Engineers, 1993. pp. 13-22
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AB - Holmium (λ = 2.09 μm) and excimer (λ = 308 nm) lasers are used for ablation of tissue. In a previous study it was demonstrated that both excimer and holmium laser pulses produce fast expanding and collapsing vapor bubbles. To investigate whether the excimer induced bubble is caused by vaporization of water, the threshold fluence for bubble formation at a bare fiber tip in water was compared between the excimer laser (pulse length 115 ns) and the Q-switched and free-running holmium lasers (pulse length 1 μs to 250 μs, respectively). To induce bubble formation by excimer laser light in water, the absorber oxybuprocaine-hydrochloride (OBP-HCl) was added to the water. Fast flash photography was used to measure the threshold fluence as a function of the water temperature (6 - 90°C) at environmental pressure. The ultraviolet excimer laser light is strongly absorbed by blood. Therefore, to document the implications of bubble formation at fluences above the tissue ablation threshold, excimer laser pulses were delivered in vitro in hemoglobin solution and in vivo in the femoral artery of the rabbit. We conclude that the principal content of the fast bubble induced by a 308 nm excimer laser pulse is water vapor. Therefore, delivery of excimer laser pulses in a water or blood environment will cause fast expanding water vapor bubbles, which may induce mechanical damage to adjacent tissue.

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