Bullied no more: When and how DNA shoves proteins around

Jonathan M. Fogg, Graham L. Randall, Bernard Pettitt, De Witt L Sumners, Sarah A. Harris, Lynn Zechiedrich

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The predominant protein-centric perspective in protein-DNA-binding studies assumes that the protein drives the interaction. Research focuses on protein structural motifs, electrostatic surfaces and contact potentials, while DNA is often ignored as a passive polymer to be manipulated. Recent studies of DNA topology, the supercoiling, knotting, and linking of the helices, have shown that DNA has the capability to be an active participant in its transactions. DNA topology-induced structural and geometric changes can drive, or at least strongly influence, the interactions between protein and DNA. Deformations of the B-form structure arise from both the considerable elastic energy arising from supercoiling and from the electrostatic energy. Here, we discuss how these energies are harnessed for topology-driven, sequence-specific deformations that can allow DNA to direct its own metabolism.

Original languageEnglish (US)
Pages (from-to)257-299
Number of pages43
JournalQuarterly Reviews of Biophysics
Volume45
Issue number3
DOIs
StatePublished - Aug 2012
Externally publishedYes

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Bullying
DNA
Proteins
Static Electricity
Amino Acid Motifs
DNA-Binding Proteins
Polymers
Research

ASJC Scopus subject areas

  • Biophysics

Cite this

Fogg, J. M., Randall, G. L., Pettitt, B., Sumners, D. W. L., Harris, S. A., & Zechiedrich, L. (2012). Bullied no more: When and how DNA shoves proteins around. Quarterly Reviews of Biophysics, 45(3), 257-299. https://doi.org/10.1017/S0033583512000054

Bullied no more : When and how DNA shoves proteins around. / Fogg, Jonathan M.; Randall, Graham L.; Pettitt, Bernard; Sumners, De Witt L; Harris, Sarah A.; Zechiedrich, Lynn.

In: Quarterly Reviews of Biophysics, Vol. 45, No. 3, 08.2012, p. 257-299.

Research output: Contribution to journalArticle

Fogg, JM, Randall, GL, Pettitt, B, Sumners, DWL, Harris, SA & Zechiedrich, L 2012, 'Bullied no more: When and how DNA shoves proteins around', Quarterly Reviews of Biophysics, vol. 45, no. 3, pp. 257-299. https://doi.org/10.1017/S0033583512000054
Fogg, Jonathan M. ; Randall, Graham L. ; Pettitt, Bernard ; Sumners, De Witt L ; Harris, Sarah A. ; Zechiedrich, Lynn. / Bullied no more : When and how DNA shoves proteins around. In: Quarterly Reviews of Biophysics. 2012 ; Vol. 45, No. 3. pp. 257-299.
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