Bupivacaine drug-induced liver injury

A case series and brief review of the literature

Preethi Chintamaneni, Heather Stevenson-Lerner, Shahid M. Malik

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Bupivacaine is an established and efficacious anesthetic that has become increasingly popular in postoperative pain management. However, there is limited literature regarding the potential for bupivacaine-induced delayed liver toxicity. Describe cholestasis as a potential adverse reaction of bupivacaine infusion into a surgical wound. Retrospective review of patients' medical records. We report the cases of 3 patients with new onset of cholestatic injury after receiving bupivacaine infusion for postoperative herniorrhaphy pain management. All patients had negative serologic workups for other causes of liver injury. All patients achieved eventual resolution of their liver injury. Bupivacaine-induced liver injury should be on the differential of individuals presenting with jaundice and cholestasis within a month of infusion via a surgically placed catheter of this commonly used anesthetic.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalJournal of Clinical Anesthesia
Volume32
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Fingerprint

Chemical and Drug Induced Liver Injury
Bupivacaine
Liver
Cholestasis
Wounds and Injuries
Pain Management
Postoperative Pain
Anesthetics
Herniorrhaphy
Jaundice
Medical Records
Catheters

Keywords

  • Analgesics
  • Bupivacaine
  • Cholestasis
  • Drug induced liver injury

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Bupivacaine drug-induced liver injury : A case series and brief review of the literature. / Chintamaneni, Preethi; Stevenson-Lerner, Heather; Malik, Shahid M.

In: Journal of Clinical Anesthesia, Vol. 32, 01.08.2016, p. 137-141.

Research output: Contribution to journalArticle

@article{0a3e5159f50340a6b19d5ab6ba9347c5,
title = "Bupivacaine drug-induced liver injury: A case series and brief review of the literature",
abstract = "Bupivacaine is an established and efficacious anesthetic that has become increasingly popular in postoperative pain management. However, there is limited literature regarding the potential for bupivacaine-induced delayed liver toxicity. Describe cholestasis as a potential adverse reaction of bupivacaine infusion into a surgical wound. Retrospective review of patients' medical records. We report the cases of 3 patients with new onset of cholestatic injury after receiving bupivacaine infusion for postoperative herniorrhaphy pain management. All patients had negative serologic workups for other causes of liver injury. All patients achieved eventual resolution of their liver injury. Bupivacaine-induced liver injury should be on the differential of individuals presenting with jaundice and cholestasis within a month of infusion via a surgically placed catheter of this commonly used anesthetic.",
keywords = "Analgesics, Bupivacaine, Cholestasis, Drug induced liver injury",
author = "Preethi Chintamaneni and Heather Stevenson-Lerner and Malik, {Shahid M.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1016/j.jclinane.2016.01.035",
language = "English (US)",
volume = "32",
pages = "137--141",
journal = "Journal of Clinical Anesthesia",
issn = "0952-8180",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Bupivacaine drug-induced liver injury

T2 - A case series and brief review of the literature

AU - Chintamaneni, Preethi

AU - Stevenson-Lerner, Heather

AU - Malik, Shahid M.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Bupivacaine is an established and efficacious anesthetic that has become increasingly popular in postoperative pain management. However, there is limited literature regarding the potential for bupivacaine-induced delayed liver toxicity. Describe cholestasis as a potential adverse reaction of bupivacaine infusion into a surgical wound. Retrospective review of patients' medical records. We report the cases of 3 patients with new onset of cholestatic injury after receiving bupivacaine infusion for postoperative herniorrhaphy pain management. All patients had negative serologic workups for other causes of liver injury. All patients achieved eventual resolution of their liver injury. Bupivacaine-induced liver injury should be on the differential of individuals presenting with jaundice and cholestasis within a month of infusion via a surgically placed catheter of this commonly used anesthetic.

AB - Bupivacaine is an established and efficacious anesthetic that has become increasingly popular in postoperative pain management. However, there is limited literature regarding the potential for bupivacaine-induced delayed liver toxicity. Describe cholestasis as a potential adverse reaction of bupivacaine infusion into a surgical wound. Retrospective review of patients' medical records. We report the cases of 3 patients with new onset of cholestatic injury after receiving bupivacaine infusion for postoperative herniorrhaphy pain management. All patients had negative serologic workups for other causes of liver injury. All patients achieved eventual resolution of their liver injury. Bupivacaine-induced liver injury should be on the differential of individuals presenting with jaundice and cholestasis within a month of infusion via a surgically placed catheter of this commonly used anesthetic.

KW - Analgesics

KW - Bupivacaine

KW - Cholestasis

KW - Drug induced liver injury

UR - http://www.scopus.com/inward/record.url?scp=84964381009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964381009&partnerID=8YFLogxK

U2 - 10.1016/j.jclinane.2016.01.035

DO - 10.1016/j.jclinane.2016.01.035

M3 - Article

VL - 32

SP - 137

EP - 141

JO - Journal of Clinical Anesthesia

JF - Journal of Clinical Anesthesia

SN - 0952-8180

ER -