@article{ad42f8f87785493a8547f7f72881d729,
title = "C5a is not involved in experimental autoimmune myasthenia gravis pathogenesis",
abstract = "C5 deficient mice are highly resistant to experimental autoimmune myasthenia gravis (EAMG) despite intact immune response to acethylcholine receptor (AChR), validating the pivotal role played by membrane attack complex (MAC, C5b-9) in neuromuscular junction destruction. To distinguish the significance of C5a from that of C5b in EAMG pathogenesis, C5a receptor (C5aR) knockout (KO) and wild-type (WT) mice were immunized with AChR to induce pathogenic anti-AChR antibodies. In contrast with C5 deficient mice, C5aR KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and lymphocyte proliferation response to AChR implicating that C5a is not involved in EAMG development.",
keywords = "Autoimmunity, C5a, C5a receptor, Myasthenia gravis",
author = "Huibin Qi and Erdem T{\"u}z{\"u}n and Windy Allman and Saini, {Shamsher S.} and Penabad, {Zurina R.} and Silvia Pierangeli and Premkumar Christadoss",
note = "Funding Information: Erdem T{\"u}z{\"u}n was a Myasthenia Gravis foundation Osserman/Sosin/McClure Postdoctoral Fellowship recipient and was an MDA Neuromuscular Disease Research Career Award recipient. Windy Allman is a recipient of a Henry Viets Fellowship from the MG foundation of America and a predoctoral fellowship from AFM. Funding Information: This study is supported by the Muscular Dystrophy Association and AFM (PC), and partially supported by a Research Centers in Minority Institutions_National Institutes of Health grant (G-12-RR03034), a Minority Biomedical Research Support Grant from the National Institutes of Health (GM58268002) and a NIAMS NIH Multidisciplinary Research Center Grant (2P60 AR047785-06) (SSP and ZRP). ",
year = "2008",
month = may,
day = "30",
doi = "10.1016/j.jneuroim.2008.03.007",
language = "English (US)",
volume = "196",
pages = "101--106",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",
}