Cadaver donor discards secondary to serology

J. R. Barnett, R. L. McCauley, S. Schutzler, K. Sheridan, J. P. Heggers

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    The use of cadaveric skin has made a major impact in the survival of patients experiencing major thermal injury. However, the availability of cadaveric skin is often limited by potentially pathogenic organisms. Very little data exists as to why cadaveric skin from donors who have been previously screened was discarded. From March 1994 to March 1996, 813 donors were referred to our tissue bank. All donors were reviewed for the cause of death, history and physical, and social history. One hundred fifty-three donors screened were discarded. Sixty-one donors of this group were discarded because of positive serologies. The following are the percentages of the specific positive serologies: hepatitis B core antibody, 52.3%; hepatitis B surface antigen, 18.1%; hepatitis C virus antibody, 14.3%; human immunodeficiency virus antibody, 4.9%; human T lymphocyte virus antibody, 4.9% and syphilis, 5.5%. Retrospectively, all donor screening questionnaires were reviewed for possible indicators in relation to positive serologic testing. Current screening methods, although excellent in social screening, still fail to identify a significant number of donors who may have positive serologies because of hepatitis, human immunodeficiency virus, human T lymphocyte virus, or syphilis. As the field of tissue banking continues to evolve, the focus will need to be directed toward better screening mechanisms in order to decrease our current discard rates after donors have been approved through the screening process.

    Original languageEnglish (US)
    Pages (from-to)124-127
    Number of pages4
    JournalJournal of Burn Care and Rehabilitation
    Volume22
    Issue number2
    StatePublished - 2001

    Fingerprint

    Serology
    Cadaver
    Tissue Donors
    Tissue Banks
    Syphilis
    Skin
    History
    HIV
    Viruses
    T-Lymphocytes
    Hepatitis B Antibodies
    Donor Selection
    Hepatitis C Antibodies
    Antibodies
    Hepatitis B Surface Antigens
    Hepatitis
    Cause of Death
    Hot Temperature
    Survival
    Wounds and Injuries

    ASJC Scopus subject areas

    • Rehabilitation
    • Surgery
    • Nursing(all)
    • Health Professions(all)
    • Emergency Medicine

    Cite this

    Barnett, J. R., McCauley, R. L., Schutzler, S., Sheridan, K., & Heggers, J. P. (2001). Cadaver donor discards secondary to serology. Journal of Burn Care and Rehabilitation, 22(2), 124-127.

    Cadaver donor discards secondary to serology. / Barnett, J. R.; McCauley, R. L.; Schutzler, S.; Sheridan, K.; Heggers, J. P.

    In: Journal of Burn Care and Rehabilitation, Vol. 22, No. 2, 2001, p. 124-127.

    Research output: Contribution to journalArticle

    Barnett, JR, McCauley, RL, Schutzler, S, Sheridan, K & Heggers, JP 2001, 'Cadaver donor discards secondary to serology', Journal of Burn Care and Rehabilitation, vol. 22, no. 2, pp. 124-127.
    Barnett JR, McCauley RL, Schutzler S, Sheridan K, Heggers JP. Cadaver donor discards secondary to serology. Journal of Burn Care and Rehabilitation. 2001;22(2):124-127.
    Barnett, J. R. ; McCauley, R. L. ; Schutzler, S. ; Sheridan, K. ; Heggers, J. P. / Cadaver donor discards secondary to serology. In: Journal of Burn Care and Rehabilitation. 2001 ; Vol. 22, No. 2. pp. 124-127.
    @article{c035a59866f24d2081da8e143340a8a8,
    title = "Cadaver donor discards secondary to serology",
    abstract = "The use of cadaveric skin has made a major impact in the survival of patients experiencing major thermal injury. However, the availability of cadaveric skin is often limited by potentially pathogenic organisms. Very little data exists as to why cadaveric skin from donors who have been previously screened was discarded. From March 1994 to March 1996, 813 donors were referred to our tissue bank. All donors were reviewed for the cause of death, history and physical, and social history. One hundred fifty-three donors screened were discarded. Sixty-one donors of this group were discarded because of positive serologies. The following are the percentages of the specific positive serologies: hepatitis B core antibody, 52.3{\%}; hepatitis B surface antigen, 18.1{\%}; hepatitis C virus antibody, 14.3{\%}; human immunodeficiency virus antibody, 4.9{\%}; human T lymphocyte virus antibody, 4.9{\%} and syphilis, 5.5{\%}. Retrospectively, all donor screening questionnaires were reviewed for possible indicators in relation to positive serologic testing. Current screening methods, although excellent in social screening, still fail to identify a significant number of donors who may have positive serologies because of hepatitis, human immunodeficiency virus, human T lymphocyte virus, or syphilis. As the field of tissue banking continues to evolve, the focus will need to be directed toward better screening mechanisms in order to decrease our current discard rates after donors have been approved through the screening process.",
    author = "Barnett, {J. R.} and McCauley, {R. L.} and S. Schutzler and K. Sheridan and Heggers, {J. P.}",
    year = "2001",
    language = "English (US)",
    volume = "22",
    pages = "124--127",
    journal = "Journal of Burn Care and Research",
    issn = "1559-047X",
    publisher = "Lippincott Williams and Wilkins",
    number = "2",

    }

    TY - JOUR

    T1 - Cadaver donor discards secondary to serology

    AU - Barnett, J. R.

    AU - McCauley, R. L.

    AU - Schutzler, S.

    AU - Sheridan, K.

    AU - Heggers, J. P.

    PY - 2001

    Y1 - 2001

    N2 - The use of cadaveric skin has made a major impact in the survival of patients experiencing major thermal injury. However, the availability of cadaveric skin is often limited by potentially pathogenic organisms. Very little data exists as to why cadaveric skin from donors who have been previously screened was discarded. From March 1994 to March 1996, 813 donors were referred to our tissue bank. All donors were reviewed for the cause of death, history and physical, and social history. One hundred fifty-three donors screened were discarded. Sixty-one donors of this group were discarded because of positive serologies. The following are the percentages of the specific positive serologies: hepatitis B core antibody, 52.3%; hepatitis B surface antigen, 18.1%; hepatitis C virus antibody, 14.3%; human immunodeficiency virus antibody, 4.9%; human T lymphocyte virus antibody, 4.9% and syphilis, 5.5%. Retrospectively, all donor screening questionnaires were reviewed for possible indicators in relation to positive serologic testing. Current screening methods, although excellent in social screening, still fail to identify a significant number of donors who may have positive serologies because of hepatitis, human immunodeficiency virus, human T lymphocyte virus, or syphilis. As the field of tissue banking continues to evolve, the focus will need to be directed toward better screening mechanisms in order to decrease our current discard rates after donors have been approved through the screening process.

    AB - The use of cadaveric skin has made a major impact in the survival of patients experiencing major thermal injury. However, the availability of cadaveric skin is often limited by potentially pathogenic organisms. Very little data exists as to why cadaveric skin from donors who have been previously screened was discarded. From March 1994 to March 1996, 813 donors were referred to our tissue bank. All donors were reviewed for the cause of death, history and physical, and social history. One hundred fifty-three donors screened were discarded. Sixty-one donors of this group were discarded because of positive serologies. The following are the percentages of the specific positive serologies: hepatitis B core antibody, 52.3%; hepatitis B surface antigen, 18.1%; hepatitis C virus antibody, 14.3%; human immunodeficiency virus antibody, 4.9%; human T lymphocyte virus antibody, 4.9% and syphilis, 5.5%. Retrospectively, all donor screening questionnaires were reviewed for possible indicators in relation to positive serologic testing. Current screening methods, although excellent in social screening, still fail to identify a significant number of donors who may have positive serologies because of hepatitis, human immunodeficiency virus, human T lymphocyte virus, or syphilis. As the field of tissue banking continues to evolve, the focus will need to be directed toward better screening mechanisms in order to decrease our current discard rates after donors have been approved through the screening process.

    UR - http://www.scopus.com/inward/record.url?scp=0035075172&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0035075172&partnerID=8YFLogxK

    M3 - Article

    C2 - 11302599

    AN - SCOPUS:0035075172

    VL - 22

    SP - 124

    EP - 127

    JO - Journal of Burn Care and Research

    JF - Journal of Burn Care and Research

    SN - 1559-047X

    IS - 2

    ER -