Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects

Mai F. Tolba, Samar S. Azab, Amani E. Khalifa, Sherif Abdel-Rahman, Ashraf B. Abdel-Naim

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Caffeic acid phenethyl ester (CAPE) is an important active component of honey bee propolis that possesses a plethora of biological activities. Propolis is used safely in traditional medicine as a dietary supplement for its therapeutic benefits. This review highlights the recently published data about CAPE bioavailability, anti-inflammatory, neuroprotective; hepatoprotective and cardioprotective activities. CAPE showed promising efficacy both in vitro and in vivo studies in animal models with minimum adverse effects. Its effectiveness was demonstrated in multiple target organs. Despite this fact, it has not been yet investigated as a protective agent or a potential therapy in humans. Investigation of CAPE efficacy in clinical trials is strongly encouraged to elucidate its therapeutic benefit for different human diseases after performing full preclinical toxicological studies and gaining more insights into its pharmacokinetics.

Original languageEnglish (US)
Pages (from-to)699-709
Number of pages11
JournalIUBMB Life
Volume65
Issue number8
DOIs
StatePublished - Aug 2013

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Propolis
Bioactivity
Anti-Inflammatory Agents
Dietary supplements
Protective Agents
Pharmacokinetics
Honey
Bees
Traditional Medicine
Dietary Supplements
Toxicology
Biological Availability
Medicine
Animals
Therapeutics
Animal Models
Clinical Trials
caffeic acid phenethyl ester

Keywords

  • anti-inflammatory
  • bioavailability
  • caffeic acid phenethyl ester (CAPE)
  • cardioprotective
  • hepatoprotective
  • neuroprotective

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities : A review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects. / Tolba, Mai F.; Azab, Samar S.; Khalifa, Amani E.; Abdel-Rahman, Sherif; Abdel-Naim, Ashraf B.

In: IUBMB Life, Vol. 65, No. 8, 08.2013, p. 699-709.

Research output: Contribution to journalArticle

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