Calcifying Nanoparticles (Nanobacteria)

An Additional Potential Factor for Urolithiasis in Space Flight Crews

Jeffrey A. Jones, Neva Ciftcioglu, Josef F. Schmid, Yael R. Barr, Donald Griffith

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Spaceflight-induced microgravity appears to be a risk factor for the development of urinary calculi, resulting in urolithiasis during and after spaceflight. Calcifying nanoparticles, or nanobacteria, multiply more rapidly in simulated microgravity and create external shells of calcium phosphate. The question arises whether calcifying nanoparticles are nidi for calculi and contribute to the development of clinically significant urolithiasis in those who are predisposed to the development of urinary calculi because of intrinsic or extrinsic factors. This case report describes a calculus recovered after flight from an astronaut that, on morphologic and immunochemical analysis (including specific monoclonal antibody staining), demonstrated characteristics of calcifying nanoparticles.

Original languageEnglish (US)
JournalUrology
Volume73
Issue number1
DOIs
StatePublished - Jan 2009

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Calcifying Nanoparticles
Space Flight
Urolithiasis
Weightlessness
Urinary Calculi
Calculi
Astronauts
Monoclonal Antibodies
Staining and Labeling

ASJC Scopus subject areas

  • Urology

Cite this

Calcifying Nanoparticles (Nanobacteria) : An Additional Potential Factor for Urolithiasis in Space Flight Crews. / Jones, Jeffrey A.; Ciftcioglu, Neva; Schmid, Josef F.; Barr, Yael R.; Griffith, Donald.

In: Urology, Vol. 73, No. 1, 01.2009.

Research output: Contribution to journalArticle

Jones, Jeffrey A. ; Ciftcioglu, Neva ; Schmid, Josef F. ; Barr, Yael R. ; Griffith, Donald. / Calcifying Nanoparticles (Nanobacteria) : An Additional Potential Factor for Urolithiasis in Space Flight Crews. In: Urology. 2009 ; Vol. 73, No. 1.
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