Calcitonin gene related family peptides: Importance in normal placental and fetal development

Chandra Yallampalli, Madhu Chauhan, Janice Endsley, Kunju Sathishkumar

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations


Synchronized molecular and cellular events occur between the uterus and the implanting embryo to facilitate successful pregnancy outcome. Nevertheless, the molecular signaling network that coordinates strategies for successful decidualization, placentation and fetal growth are not well understood. The discovery of calcitonin/calcitonin gene-related peptides (CT/CGRP) highlighted new signaling mediators in various physiological processes, including reproduction. It is known that CGRP family peptides including CGRP, adrenomedulin and intermedin play regulatory functions during implantation, trophoblast proliferation and invasion, and fetal organogenesis. In addition, all the CGRP family peptides and their receptor components are found to be expressed in decidual, placental and fetal tissues. Additionally, plasma levels of peptides of the CGRP family were found to fluctuate during normal gestation and to induce placental cellular differentiation, proliferation, and critical hormone signaling. Moreover, aberrant signaling of these CGRP family peptides during gestation has been associated with pregnancy disorders. It indicates the existence of a possible regulatory role for these molecules during decidualization and placentation processes, which are known to be particularly vulnerable. In this review, the influence of the CGRP family peptides in these critical processes is explored and discussed.

Original languageEnglish (US)
Title of host publicationAdvances in Fetal and Neonatal Physiology
Subtitle of host publicationProceedings of the Center for Perinatal Biology 40th Anniversary Symposium
PublisherSpringer New York LLC
Number of pages12
ISBN (Print)9781493910304
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Adrenomedullin
  • CGRP
  • Decidua
  • Implantation
  • Intermedin
  • Organogenesis
  • Placentation
  • Pregnancy disorders
  • RAMP
  • Trophoblast

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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