Calcitonin gene related family peptides: importance in normal placental and fetal development

Chandra Yallampalli, Madhu Chauhan, Janice Endsley, Kunju Sathishkumar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Synchronized molecular and cellular events occur between the uterus and the implanting embryo to facilitate successful pregnancy outcome. Nevertheless, the molecular signaling network that coordinates strategies for successful decidualization, placentation and fetal growth are not well understood. The discovery of calcitonin/calcitonin gene-related peptides (CT/CGRP) highlighted new signaling mediators in various physiological processes, including reproduction. It is known that CGRP family peptides including CGRP, adrenomedulin and intermedin play regulatory functions during implantation, trophoblast proliferation and invasion, and fetal organogenesis. In addition, all the CGRP family peptides and their receptor components are found to be expressed in decidual, placental and fetal tissues. Additionally, plasma levels of peptides of the CGRP family were found to fluctuate during normal gestation and to induce placental cellular differentiation, proliferation, and critical hormone signaling. Moreover, aberrant signaling of these CGRP family peptides during gestation has been associated with pregnancy disorders. It indicates the existence of a possible regulatory role for these molecules during decidualization and placentation processes, which are known to be particularly vulnerable. In this review, the influence of the CGRP family peptides in these critical processes is explored and discussed.

Original languageEnglish (US)
Pages (from-to)229-240
Number of pages12
JournalAdvances in Experimental Medicine and Biology
Volume814
DOIs
StatePublished - 2014

Fingerprint

Placentation
Calcitonin Gene-Related Peptide
Calcitonin
Fetal Development
Genes
Peptides
Pregnancy
Physiological Phenomena
Peptide Receptors
Organogenesis
Trophoblasts
Pregnancy Outcome
Uterus
Reproduction
Fetus
Embryonic Structures
Cell Proliferation
Hormones
Tissue
Plasmas

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Calcitonin gene related family peptides : importance in normal placental and fetal development. / Yallampalli, Chandra; Chauhan, Madhu; Endsley, Janice; Sathishkumar, Kunju.

In: Advances in Experimental Medicine and Biology, Vol. 814, 2014, p. 229-240.

Research output: Contribution to journalArticle

@article{540fd8ebc15d473b9d2cbbcf655ec6a0,
title = "Calcitonin gene related family peptides: importance in normal placental and fetal development",
abstract = "Synchronized molecular and cellular events occur between the uterus and the implanting embryo to facilitate successful pregnancy outcome. Nevertheless, the molecular signaling network that coordinates strategies for successful decidualization, placentation and fetal growth are not well understood. The discovery of calcitonin/calcitonin gene-related peptides (CT/CGRP) highlighted new signaling mediators in various physiological processes, including reproduction. It is known that CGRP family peptides including CGRP, adrenomedulin and intermedin play regulatory functions during implantation, trophoblast proliferation and invasion, and fetal organogenesis. In addition, all the CGRP family peptides and their receptor components are found to be expressed in decidual, placental and fetal tissues. Additionally, plasma levels of peptides of the CGRP family were found to fluctuate during normal gestation and to induce placental cellular differentiation, proliferation, and critical hormone signaling. Moreover, aberrant signaling of these CGRP family peptides during gestation has been associated with pregnancy disorders. It indicates the existence of a possible regulatory role for these molecules during decidualization and placentation processes, which are known to be particularly vulnerable. In this review, the influence of the CGRP family peptides in these critical processes is explored and discussed.",
author = "Chandra Yallampalli and Madhu Chauhan and Janice Endsley and Kunju Sathishkumar",
year = "2014",
doi = "10.1007/978-1-4939-1031-1_20",
language = "English (US)",
volume = "814",
pages = "229--240",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer New York",

}

TY - JOUR

T1 - Calcitonin gene related family peptides

T2 - importance in normal placental and fetal development

AU - Yallampalli, Chandra

AU - Chauhan, Madhu

AU - Endsley, Janice

AU - Sathishkumar, Kunju

PY - 2014

Y1 - 2014

N2 - Synchronized molecular and cellular events occur between the uterus and the implanting embryo to facilitate successful pregnancy outcome. Nevertheless, the molecular signaling network that coordinates strategies for successful decidualization, placentation and fetal growth are not well understood. The discovery of calcitonin/calcitonin gene-related peptides (CT/CGRP) highlighted new signaling mediators in various physiological processes, including reproduction. It is known that CGRP family peptides including CGRP, adrenomedulin and intermedin play regulatory functions during implantation, trophoblast proliferation and invasion, and fetal organogenesis. In addition, all the CGRP family peptides and their receptor components are found to be expressed in decidual, placental and fetal tissues. Additionally, plasma levels of peptides of the CGRP family were found to fluctuate during normal gestation and to induce placental cellular differentiation, proliferation, and critical hormone signaling. Moreover, aberrant signaling of these CGRP family peptides during gestation has been associated with pregnancy disorders. It indicates the existence of a possible regulatory role for these molecules during decidualization and placentation processes, which are known to be particularly vulnerable. In this review, the influence of the CGRP family peptides in these critical processes is explored and discussed.

AB - Synchronized molecular and cellular events occur between the uterus and the implanting embryo to facilitate successful pregnancy outcome. Nevertheless, the molecular signaling network that coordinates strategies for successful decidualization, placentation and fetal growth are not well understood. The discovery of calcitonin/calcitonin gene-related peptides (CT/CGRP) highlighted new signaling mediators in various physiological processes, including reproduction. It is known that CGRP family peptides including CGRP, adrenomedulin and intermedin play regulatory functions during implantation, trophoblast proliferation and invasion, and fetal organogenesis. In addition, all the CGRP family peptides and their receptor components are found to be expressed in decidual, placental and fetal tissues. Additionally, plasma levels of peptides of the CGRP family were found to fluctuate during normal gestation and to induce placental cellular differentiation, proliferation, and critical hormone signaling. Moreover, aberrant signaling of these CGRP family peptides during gestation has been associated with pregnancy disorders. It indicates the existence of a possible regulatory role for these molecules during decidualization and placentation processes, which are known to be particularly vulnerable. In this review, the influence of the CGRP family peptides in these critical processes is explored and discussed.

UR - http://www.scopus.com/inward/record.url?scp=84921691638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921691638&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-1031-1_20

DO - 10.1007/978-1-4939-1031-1_20

M3 - Article

C2 - 25015815

AN - SCOPUS:84921691638

VL - 814

SP - 229

EP - 240

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -