Calcitonin gene-related family peptides in vascular adaptations, uteroplacental circulation, and fetal growth

Chandra Yallampalli, Madhu Chauhan, K. Sathishkumar

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Maternal vascular adaptations, implantation of embryo, and placental growth and development are crucial for overall well-being of the fetus and are controlled by a range of signals, including growth factors and steroid hormones. The calcitonin (CT)/calcitonin gene-related peptide (CGRP) family peptides have been the focus of emerging studies, and these peptides appear to mediate some of the critical functions during pregnancy. Three peptides of the CT/CGRP family, CGRP, adrenomedullin, and intermedin, working through their overlapping receptor components, exert significant positive effects on vascular adaptations during pregnancy, uteroplacental vascular functions, and fetal growth. Many of the effects of these peptides are regulated by sex steroid hormones. Use of peptide antagonist in animals, together with genetic animal models, strongly implicates the importance of these 3 peptides in human pregnancy and related complications. However, insights into the underlying mechanisms of their actions on fetal-placental growth are limited by the lack of specificity of currently available antagonists. Future studies with specific knockdown of receptor components and/or peptides should be helpful for better understanding of these mechanisms and for the development of target-specific therapies to prevent pregnancy complications.

    Original languageEnglish (US)
    Pages (from-to)641-654
    Number of pages14
    JournalCurrent Vascular Pharmacology
    Volume11
    Issue number5
    StatePublished - 2013

    Fingerprint

    Placental Circulation
    Calcitonin Gene-Related Peptide
    Fetal Development
    Blood Vessels
    Peptides
    Pregnancy Complications
    Calcitonin
    Adrenomedullin
    Placentation
    Pregnancy
    Genetic Models
    Gonadal Steroid Hormones
    Growth and Development
    Intercellular Signaling Peptides and Proteins
    Fetus
    Animal Models
    Steroids
    Mothers
    Hormones

    Keywords

    • Adrenomedullin
    • Blood pressure
    • CRLR
    • Intermedin
    • Placenta
    • Preeclampsia
    • Pregnancy
    • RAMP

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Pharmacology

    Cite this

    Calcitonin gene-related family peptides in vascular adaptations, uteroplacental circulation, and fetal growth. / Yallampalli, Chandra; Chauhan, Madhu; Sathishkumar, K.

    In: Current Vascular Pharmacology, Vol. 11, No. 5, 2013, p. 641-654.

    Research output: Contribution to journalArticle

    Yallampalli, Chandra ; Chauhan, Madhu ; Sathishkumar, K. / Calcitonin gene-related family peptides in vascular adaptations, uteroplacental circulation, and fetal growth. In: Current Vascular Pharmacology. 2013 ; Vol. 11, No. 5. pp. 641-654.
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