Abstract
Spinothalamic tract (STT) cells were identified by intracellular injection or retrograde labeling with horseradish peroxidase (HRP) in the primate spinal cord. Using immunohistochemical techniques, a population of primary afferents containing calcitonin gene-related peptide (CGRP) is demonstrated in synaptic contact with these neurons. Large glomerular type CGRP terminals with morphology considered typical of primary afferent fibers are occasionally observed in contact with STT profiles in laminae I and IIo; however, this morphological type targets STT profiles chiefly in the deeper dorsal horn (laminae III, IV and V). In contrast, the majority of CGRP terminals contacting STT profiles in the superficial dorsal horn (laminae I and IIo), are small, round or oblong shaped terminals. Thus, evidenced by these data, the absence of large, glomerular type terminals does not rule out primary afferent input.
Original language | English (US) |
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Pages (from-to) | 76-81 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 109 |
Issue number | 1-2 |
DOIs | |
State | Published - Feb 5 1990 |
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Keywords
- Antinociception
- Calcitonin gene-related peptide
- Monkey
- Spinal cord
- Ultrastructure
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells. / Carlton, Susan M.; Westlund, Karin N.; Zhang, Dongxian; Sorkin, Linda S.; Willis, William D.
In: Neuroscience Letters, Vol. 109, No. 1-2, 05.02.1990, p. 76-81.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells
AU - Carlton, Susan M.
AU - Westlund, Karin N.
AU - Zhang, Dongxian
AU - Sorkin, Linda S.
AU - Willis, William D.
PY - 1990/2/5
Y1 - 1990/2/5
N2 - Spinothalamic tract (STT) cells were identified by intracellular injection or retrograde labeling with horseradish peroxidase (HRP) in the primate spinal cord. Using immunohistochemical techniques, a population of primary afferents containing calcitonin gene-related peptide (CGRP) is demonstrated in synaptic contact with these neurons. Large glomerular type CGRP terminals with morphology considered typical of primary afferent fibers are occasionally observed in contact with STT profiles in laminae I and IIo; however, this morphological type targets STT profiles chiefly in the deeper dorsal horn (laminae III, IV and V). In contrast, the majority of CGRP terminals contacting STT profiles in the superficial dorsal horn (laminae I and IIo), are small, round or oblong shaped terminals. Thus, evidenced by these data, the absence of large, glomerular type terminals does not rule out primary afferent input.
AB - Spinothalamic tract (STT) cells were identified by intracellular injection or retrograde labeling with horseradish peroxidase (HRP) in the primate spinal cord. Using immunohistochemical techniques, a population of primary afferents containing calcitonin gene-related peptide (CGRP) is demonstrated in synaptic contact with these neurons. Large glomerular type CGRP terminals with morphology considered typical of primary afferent fibers are occasionally observed in contact with STT profiles in laminae I and IIo; however, this morphological type targets STT profiles chiefly in the deeper dorsal horn (laminae III, IV and V). In contrast, the majority of CGRP terminals contacting STT profiles in the superficial dorsal horn (laminae I and IIo), are small, round or oblong shaped terminals. Thus, evidenced by these data, the absence of large, glomerular type terminals does not rule out primary afferent input.
KW - Antinociception
KW - Calcitonin gene-related peptide
KW - Monkey
KW - Spinal cord
KW - Ultrastructure
UR - http://www.scopus.com/inward/record.url?scp=0025189819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025189819&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(90)90540-P
DO - 10.1016/0304-3940(90)90540-P
M3 - Article
C2 - 2314643
AN - SCOPUS:0025189819
VL - 109
SP - 76
EP - 81
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -