Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells

Susan M. Carlton, Karin N. Westlund, Dongxian Zhang, Linda S. Sorkin, William D. Willis

    Research output: Contribution to journal › Article

    47 Citations (Scopus)

    Abstract

    Spinothalamic tract (STT) cells were identified by intracellular injection or retrograde labeling with horseradish peroxidase (HRP) in the primate spinal cord. Using immunohistochemical techniques, a population of primary afferents containing calcitonin gene-related peptide (CGRP) is demonstrated in synaptic contact with these neurons. Large glomerular type CGRP terminals with morphology considered typical of primary afferent fibers are occasionally observed in contact with STT profiles in laminae I and IIo; however, this morphological type targets STT profiles chiefly in the deeper dorsal horn (laminae III, IV and V). In contrast, the majority of CGRP terminals contacting STT profiles in the superficial dorsal horn (laminae I and IIo), are small, round or oblong shaped terminals. Thus, evidenced by these data, the absence of large, glomerular type terminals does not rule out primary afferent input.

    Original languageEnglish (US)
    Pages (from-to)76-81
    Number of pages6
    JournalNeuroscience Letters
    Volume109
    Issue number1-2
    DOIs
    StatePublished - Feb 5 1990

    Fingerprint

    Spinothalamic Tracts
    Calcitonin Gene-Related Peptide
    Synapses
    Primates
    Horseradish Peroxidase
    Spinal Cord
    Spinal Cord Dorsal Horn
    Neurons
    Injections
    Population

    Keywords

    • Antinociception
    • Calcitonin gene-related peptide
    • Monkey
    • Spinal cord
    • Ultrastructure

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells. / Carlton, Susan M.; Westlund, Karin N.; Zhang, Dongxian; Sorkin, Linda S.; Willis, William D.

    In: Neuroscience Letters, Vol. 109, No. 1-2, 05.02.1990, p. 76-81.

    Research output: Contribution to journal › Article

    Carlton, SM, Westlund, KN, Zhang, D, Sorkin, LS & Willis, WD 1990, 'Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells', Neuroscience Letters, vol. 109, no. 1-2, pp. 76-81. https://doi.org/10.1016/0304-3940(90)90540-P
    Carlton SM, Westlund KN, Zhang D, Sorkin LS, Willis WD. Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells. Neuroscience Letters. 1990 Feb 5;109(1-2):76-81. https://doi.org/10.1016/0304-3940(90)90540-P
    Carlton, Susan M. ; Westlund, Karin N. ; Zhang, Dongxian ; Sorkin, Linda S. ; Willis, William D. / Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cells. In: Neuroscience Letters. 1990 ; Vol. 109, No. 1-2. pp. 76-81.
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    abstract = "Spinothalamic tract (STT) cells were identified by intracellular injection or retrograde labeling with horseradish peroxidase (HRP) in the primate spinal cord. Using immunohistochemical techniques, a population of primary afferents containing calcitonin gene-related peptide (CGRP) is demonstrated in synaptic contact with these neurons. Large glomerular type CGRP terminals with morphology considered typical of primary afferent fibers are occasionally observed in contact with STT profiles in laminae I and IIo; however, this morphological type targets STT profiles chiefly in the deeper dorsal horn (laminae III, IV and V). In contrast, the majority of CGRP terminals contacting STT profiles in the superficial dorsal horn (laminae I and IIo), are small, round or oblong shaped terminals. Thus, evidenced by these data, the absence of large, glomerular type terminals does not rule out primary afferent input.",
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    AU - Willis, William D.

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