Calcitonin inhibition of insulin release from isolated rat pancreatic islets

A. Alwmark; M. W. Stavinoha; C. W. Cooper; G. H. Greeley; J. C. Thompson

doi:10.2337/diab.35.1.58

Calcitonin inhibition of insulin release from isolated rat pancreatic islets

A. Alwmark, M. W. Stavinoha, C. W. Cooper, G. H. Greeley, J. C. Thompson

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Calcitonin is known to inhibit secretion of gastrin and insulin in vivo. The objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release. Isolated islets were obtained from collagenase-treated rat pancreas, and three peptides (gastrin-releasing peptide, cholecystokinin-8, bombesin) and glucose were used to stimulate insulin release. All agents caused a significant increase in insulin secretion and calcitonin inhibited these responses, but had no consistent effect on basal release. This study provides evidence that calcitonin is an effective inhibitor of insulin secretion and acts directly on islet tissue.

Original language	English (US)
Pages (from-to)	58-60
Number of pages	3
Journal	Diabetes
Volume	35
Issue number	1
DOIs	https://doi.org/10.2337/diab.35.1.58
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.2337/diab.35.1.58

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abstract = "Calcitonin is known to inhibit secretion of gastrin and insulin in vivo. The objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release. Isolated islets were obtained from collagenase-treated rat pancreas, and three peptides (gastrin-releasing peptide, cholecystokinin-8, bombesin) and glucose were used to stimulate insulin release. All agents caused a significant increase in insulin secretion and calcitonin inhibited these responses, but had no consistent effect on basal release. This study provides evidence that calcitonin is an effective inhibitor of insulin secretion and acts directly on islet tissue.",

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AU - Thompson, J. C.

PY - 1986

Y1 - 1986

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AB - Calcitonin is known to inhibit secretion of gastrin and insulin in vivo. The objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release. Isolated islets were obtained from collagenase-treated rat pancreas, and three peptides (gastrin-releasing peptide, cholecystokinin-8, bombesin) and glucose were used to stimulate insulin release. All agents caused a significant increase in insulin secretion and calcitonin inhibited these responses, but had no consistent effect on basal release. This study provides evidence that calcitonin is an effective inhibitor of insulin secretion and acts directly on islet tissue.

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Calcitonin inhibition of insulin release from isolated rat pancreatic islets

Abstract

ASJC Scopus subject areas

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