Calcitonin inhibition of insulin release from isolated rat pancreatic islets

A. Alwmark, M. W. Stavinoha, C. W. Cooper, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Calcitonin is known to inhibit secretion of gastrin and insulin in vivo. The objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release. Isolated islets were obtained from collagenase-treated rat pancreas, and three peptides (gastrin-releasing peptide, cholecystokinin-8, bombesin) and glucose were used to stimulate insulin release. All agents caused a significant increase in insulin secretion and calcitonin inhibited these responses, but had no consistent effect on basal release. This study provides evidence that calcitonin is an effective inhibitor of insulin secretion and acts directly on islet tissue.

Original languageEnglish (US)
Pages (from-to)58-60
Number of pages3
JournalDiabetes
Volume35
Issue number1
StatePublished - 1986

Fingerprint

Calcitonin
Islets of Langerhans
Insulin
Gastrin-Releasing Peptide
Bombesin
Gastrins
Collagenases
Pancreas
Glucose
Peptides

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Alwmark, A., Stavinoha, M. W., Cooper, C. W., Greeley, G. H., & Thompson, J. C. (1986). Calcitonin inhibition of insulin release from isolated rat pancreatic islets. Diabetes, 35(1), 58-60.

Calcitonin inhibition of insulin release from isolated rat pancreatic islets. / Alwmark, A.; Stavinoha, M. W.; Cooper, C. W.; Greeley, G. H.; Thompson, J. C.

In: Diabetes, Vol. 35, No. 1, 1986, p. 58-60.

Research output: Contribution to journalArticle

Alwmark, A, Stavinoha, MW, Cooper, CW, Greeley, GH & Thompson, JC 1986, 'Calcitonin inhibition of insulin release from isolated rat pancreatic islets', Diabetes, vol. 35, no. 1, pp. 58-60.
Alwmark A, Stavinoha MW, Cooper CW, Greeley GH, Thompson JC. Calcitonin inhibition of insulin release from isolated rat pancreatic islets. Diabetes. 1986;35(1):58-60.
Alwmark, A. ; Stavinoha, M. W. ; Cooper, C. W. ; Greeley, G. H. ; Thompson, J. C. / Calcitonin inhibition of insulin release from isolated rat pancreatic islets. In: Diabetes. 1986 ; Vol. 35, No. 1. pp. 58-60.
@article{10927ea413054ec79cb9e366b07d9f36,
title = "Calcitonin inhibition of insulin release from isolated rat pancreatic islets",
abstract = "Calcitonin is known to inhibit secretion of gastrin and insulin in vivo. The objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release. Isolated islets were obtained from collagenase-treated rat pancreas, and three peptides (gastrin-releasing peptide, cholecystokinin-8, bombesin) and glucose were used to stimulate insulin release. All agents caused a significant increase in insulin secretion and calcitonin inhibited these responses, but had no consistent effect on basal release. This study provides evidence that calcitonin is an effective inhibitor of insulin secretion and acts directly on islet tissue.",
author = "A. Alwmark and Stavinoha, {M. W.} and Cooper, {C. W.} and Greeley, {G. H.} and Thompson, {J. C.}",
year = "1986",
language = "English (US)",
volume = "35",
pages = "58--60",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "1",

}

TY - JOUR

T1 - Calcitonin inhibition of insulin release from isolated rat pancreatic islets

AU - Alwmark, A.

AU - Stavinoha, M. W.

AU - Cooper, C. W.

AU - Greeley, G. H.

AU - Thompson, J. C.

PY - 1986

Y1 - 1986

N2 - Calcitonin is known to inhibit secretion of gastrin and insulin in vivo. The objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release. Isolated islets were obtained from collagenase-treated rat pancreas, and three peptides (gastrin-releasing peptide, cholecystokinin-8, bombesin) and glucose were used to stimulate insulin release. All agents caused a significant increase in insulin secretion and calcitonin inhibited these responses, but had no consistent effect on basal release. This study provides evidence that calcitonin is an effective inhibitor of insulin secretion and acts directly on islet tissue.

AB - Calcitonin is known to inhibit secretion of gastrin and insulin in vivo. The objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release. Isolated islets were obtained from collagenase-treated rat pancreas, and three peptides (gastrin-releasing peptide, cholecystokinin-8, bombesin) and glucose were used to stimulate insulin release. All agents caused a significant increase in insulin secretion and calcitonin inhibited these responses, but had no consistent effect on basal release. This study provides evidence that calcitonin is an effective inhibitor of insulin secretion and acts directly on islet tissue.

UR - http://www.scopus.com/inward/record.url?scp=0022576025&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022576025&partnerID=8YFLogxK

M3 - Article

C2 - 3510139

AN - SCOPUS:0022576025

VL - 35

SP - 58

EP - 60

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 1

ER -