Calcium and phosphorus metabolism in stable renal transplant recipients

Hamid T. Khosroshahi, Mohammadali Mohajel Shoja, Sima Abedi Azar, R. Shane Tubbs, Javid Safa, Jalal Etemadi, Mohammad R. Ardalan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: This study sought to elucidate the status of calcium, phosphorus, and parathyroid hormone in patients following kidney transplant. Materials and Methods: In this cross-sectional study, 20 renal transplant recipients were evaluated. For each patient, age, sex, time since transplant, and body weight were recorded. Inclusion criteria were age > 14 years and good allograft function defined as a serum creatinine level < 132.6 μmol/L for at least 6 months after transplant. Exclusion criteria were immunosuppressive therapy other than the standard triple regimen (cyclosporine, prednisolone, and mycophenolate mofetil or azathioprine) and use of any drug known to alter calcium hemostasis. Levels of 24-hour urine calcium, phosphorus, creatinine, and uric acid, as well as concentrations of hemoglobin, serum creatinine, calcium, and phosphorus were measured. To obtain a mean value of serum intact parathyroid hormone in transplant recipients at our center, serum intact parathyroid hormone levels were additionally quantitated in another group of 30 renal transplant recipients. Results: The mean hemoglobin level was 135.6 ± 17.7 g/L, the mean serum creatinine level was 105.0 ± 15.3 μmol/L, and the mean serum calcium and phosphorus levels were 2.25 ± 0.17 mmol/L (normal range, 2.02-2.60 mmol/L) and 1.28 ± 0.24 mmol/L (normal range, 0.81-1.61 mmol/L), respectively. The mean serum intact parathyroid hormone level was 33.17 ± 14.67 ng/L (normal range, 10-60 ng/L). Mean 24-hour urine calcium and phosphorus values were 2.32 ± 1.68 mmol/day (normal, 2.49-6.24 mmol/day) and 19.77 ± 8.31 mmol/day (normal, 12.91-41.98 mmol/day), respectively. A positive correlation was found between serum calcium and alkaline phosphatase levels (r = +0.71, P = .006). Hemoglobin level was negatively correlated with serum phosphorus level (r = -0.65, P = .003) and sex (r = -0.57, P = .003) and positively correlated with urine creatinine levels (r = +0.63, P = .001). Conclusions: Renar transplant recipients with stable allograft function may have normal serum calcium, phosphorus, and intact parathyroid hormone levels. However, presence of hypocalciuria and elevated serum alkaline phosphatase levels might imply impaired calcium metabolism in these patients.

Original languageEnglish (US)
Pages (from-to)670-672
Number of pages3
JournalExperimental and Clinical Transplantation
Volume5
Issue number2
StatePublished - Dec 1 2007
Externally publishedYes

Fingerprint

Phosphorus
Calcium
Kidney
Serum
Parathyroid Hormone
Creatinine
Reference Values
Hemoglobins
Urine
Transplants
Allografts
Alkaline Phosphatase
Transplant Recipients
Phosphorus Acids
Mycophenolic Acid
Azathioprine
Immunosuppressive Agents
Prednisolone
Uric Acid
Hemostasis

Keywords

  • Biodegradation
  • Biotransformation
  • Kidney transplantation
  • Parathyroid

ASJC Scopus subject areas

  • Transplantation

Cite this

Khosroshahi, H. T., Mohajel Shoja, M., Azar, S. A., Tubbs, R. S., Safa, J., Etemadi, J., & Ardalan, M. R. (2007). Calcium and phosphorus metabolism in stable renal transplant recipients. Experimental and Clinical Transplantation, 5(2), 670-672.

Calcium and phosphorus metabolism in stable renal transplant recipients. / Khosroshahi, Hamid T.; Mohajel Shoja, Mohammadali; Azar, Sima Abedi; Tubbs, R. Shane; Safa, Javid; Etemadi, Jalal; Ardalan, Mohammad R.

In: Experimental and Clinical Transplantation, Vol. 5, No. 2, 01.12.2007, p. 670-672.

Research output: Contribution to journalArticle

Khosroshahi, HT, Mohajel Shoja, M, Azar, SA, Tubbs, RS, Safa, J, Etemadi, J & Ardalan, MR 2007, 'Calcium and phosphorus metabolism in stable renal transplant recipients', Experimental and Clinical Transplantation, vol. 5, no. 2, pp. 670-672.
Khosroshahi HT, Mohajel Shoja M, Azar SA, Tubbs RS, Safa J, Etemadi J et al. Calcium and phosphorus metabolism in stable renal transplant recipients. Experimental and Clinical Transplantation. 2007 Dec 1;5(2):670-672.
Khosroshahi, Hamid T. ; Mohajel Shoja, Mohammadali ; Azar, Sima Abedi ; Tubbs, R. Shane ; Safa, Javid ; Etemadi, Jalal ; Ardalan, Mohammad R. / Calcium and phosphorus metabolism in stable renal transplant recipients. In: Experimental and Clinical Transplantation. 2007 ; Vol. 5, No. 2. pp. 670-672.
@article{b5f91e09658f408ea61c5362865570ec,
title = "Calcium and phosphorus metabolism in stable renal transplant recipients",
abstract = "Objectives: This study sought to elucidate the status of calcium, phosphorus, and parathyroid hormone in patients following kidney transplant. Materials and Methods: In this cross-sectional study, 20 renal transplant recipients were evaluated. For each patient, age, sex, time since transplant, and body weight were recorded. Inclusion criteria were age > 14 years and good allograft function defined as a serum creatinine level < 132.6 μmol/L for at least 6 months after transplant. Exclusion criteria were immunosuppressive therapy other than the standard triple regimen (cyclosporine, prednisolone, and mycophenolate mofetil or azathioprine) and use of any drug known to alter calcium hemostasis. Levels of 24-hour urine calcium, phosphorus, creatinine, and uric acid, as well as concentrations of hemoglobin, serum creatinine, calcium, and phosphorus were measured. To obtain a mean value of serum intact parathyroid hormone in transplant recipients at our center, serum intact parathyroid hormone levels were additionally quantitated in another group of 30 renal transplant recipients. Results: The mean hemoglobin level was 135.6 ± 17.7 g/L, the mean serum creatinine level was 105.0 ± 15.3 μmol/L, and the mean serum calcium and phosphorus levels were 2.25 ± 0.17 mmol/L (normal range, 2.02-2.60 mmol/L) and 1.28 ± 0.24 mmol/L (normal range, 0.81-1.61 mmol/L), respectively. The mean serum intact parathyroid hormone level was 33.17 ± 14.67 ng/L (normal range, 10-60 ng/L). Mean 24-hour urine calcium and phosphorus values were 2.32 ± 1.68 mmol/day (normal, 2.49-6.24 mmol/day) and 19.77 ± 8.31 mmol/day (normal, 12.91-41.98 mmol/day), respectively. A positive correlation was found between serum calcium and alkaline phosphatase levels (r = +0.71, P = .006). Hemoglobin level was negatively correlated with serum phosphorus level (r = -0.65, P = .003) and sex (r = -0.57, P = .003) and positively correlated with urine creatinine levels (r = +0.63, P = .001). Conclusions: Renar transplant recipients with stable allograft function may have normal serum calcium, phosphorus, and intact parathyroid hormone levels. However, presence of hypocalciuria and elevated serum alkaline phosphatase levels might imply impaired calcium metabolism in these patients.",
keywords = "Biodegradation, Biotransformation, Kidney transplantation, Parathyroid",
author = "Khosroshahi, {Hamid T.} and {Mohajel Shoja}, Mohammadali and Azar, {Sima Abedi} and Tubbs, {R. Shane} and Javid Safa and Jalal Etemadi and Ardalan, {Mohammad R.}",
year = "2007",
month = "12",
day = "1",
language = "English (US)",
volume = "5",
pages = "670--672",
journal = "Experimental and Clinical Transplantation",
issn = "1304-0855",
publisher = "Baskent University",
number = "2",

}

TY - JOUR

T1 - Calcium and phosphorus metabolism in stable renal transplant recipients

AU - Khosroshahi, Hamid T.

AU - Mohajel Shoja, Mohammadali

AU - Azar, Sima Abedi

AU - Tubbs, R. Shane

AU - Safa, Javid

AU - Etemadi, Jalal

AU - Ardalan, Mohammad R.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Objectives: This study sought to elucidate the status of calcium, phosphorus, and parathyroid hormone in patients following kidney transplant. Materials and Methods: In this cross-sectional study, 20 renal transplant recipients were evaluated. For each patient, age, sex, time since transplant, and body weight were recorded. Inclusion criteria were age > 14 years and good allograft function defined as a serum creatinine level < 132.6 μmol/L for at least 6 months after transplant. Exclusion criteria were immunosuppressive therapy other than the standard triple regimen (cyclosporine, prednisolone, and mycophenolate mofetil or azathioprine) and use of any drug known to alter calcium hemostasis. Levels of 24-hour urine calcium, phosphorus, creatinine, and uric acid, as well as concentrations of hemoglobin, serum creatinine, calcium, and phosphorus were measured. To obtain a mean value of serum intact parathyroid hormone in transplant recipients at our center, serum intact parathyroid hormone levels were additionally quantitated in another group of 30 renal transplant recipients. Results: The mean hemoglobin level was 135.6 ± 17.7 g/L, the mean serum creatinine level was 105.0 ± 15.3 μmol/L, and the mean serum calcium and phosphorus levels were 2.25 ± 0.17 mmol/L (normal range, 2.02-2.60 mmol/L) and 1.28 ± 0.24 mmol/L (normal range, 0.81-1.61 mmol/L), respectively. The mean serum intact parathyroid hormone level was 33.17 ± 14.67 ng/L (normal range, 10-60 ng/L). Mean 24-hour urine calcium and phosphorus values were 2.32 ± 1.68 mmol/day (normal, 2.49-6.24 mmol/day) and 19.77 ± 8.31 mmol/day (normal, 12.91-41.98 mmol/day), respectively. A positive correlation was found between serum calcium and alkaline phosphatase levels (r = +0.71, P = .006). Hemoglobin level was negatively correlated with serum phosphorus level (r = -0.65, P = .003) and sex (r = -0.57, P = .003) and positively correlated with urine creatinine levels (r = +0.63, P = .001). Conclusions: Renar transplant recipients with stable allograft function may have normal serum calcium, phosphorus, and intact parathyroid hormone levels. However, presence of hypocalciuria and elevated serum alkaline phosphatase levels might imply impaired calcium metabolism in these patients.

AB - Objectives: This study sought to elucidate the status of calcium, phosphorus, and parathyroid hormone in patients following kidney transplant. Materials and Methods: In this cross-sectional study, 20 renal transplant recipients were evaluated. For each patient, age, sex, time since transplant, and body weight were recorded. Inclusion criteria were age > 14 years and good allograft function defined as a serum creatinine level < 132.6 μmol/L for at least 6 months after transplant. Exclusion criteria were immunosuppressive therapy other than the standard triple regimen (cyclosporine, prednisolone, and mycophenolate mofetil or azathioprine) and use of any drug known to alter calcium hemostasis. Levels of 24-hour urine calcium, phosphorus, creatinine, and uric acid, as well as concentrations of hemoglobin, serum creatinine, calcium, and phosphorus were measured. To obtain a mean value of serum intact parathyroid hormone in transplant recipients at our center, serum intact parathyroid hormone levels were additionally quantitated in another group of 30 renal transplant recipients. Results: The mean hemoglobin level was 135.6 ± 17.7 g/L, the mean serum creatinine level was 105.0 ± 15.3 μmol/L, and the mean serum calcium and phosphorus levels were 2.25 ± 0.17 mmol/L (normal range, 2.02-2.60 mmol/L) and 1.28 ± 0.24 mmol/L (normal range, 0.81-1.61 mmol/L), respectively. The mean serum intact parathyroid hormone level was 33.17 ± 14.67 ng/L (normal range, 10-60 ng/L). Mean 24-hour urine calcium and phosphorus values were 2.32 ± 1.68 mmol/day (normal, 2.49-6.24 mmol/day) and 19.77 ± 8.31 mmol/day (normal, 12.91-41.98 mmol/day), respectively. A positive correlation was found between serum calcium and alkaline phosphatase levels (r = +0.71, P = .006). Hemoglobin level was negatively correlated with serum phosphorus level (r = -0.65, P = .003) and sex (r = -0.57, P = .003) and positively correlated with urine creatinine levels (r = +0.63, P = .001). Conclusions: Renar transplant recipients with stable allograft function may have normal serum calcium, phosphorus, and intact parathyroid hormone levels. However, presence of hypocalciuria and elevated serum alkaline phosphatase levels might imply impaired calcium metabolism in these patients.

KW - Biodegradation

KW - Biotransformation

KW - Kidney transplantation

KW - Parathyroid

UR - http://www.scopus.com/inward/record.url?scp=38549106615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38549106615&partnerID=8YFLogxK

M3 - Article

C2 - 18194119

AN - SCOPUS:38549106615

VL - 5

SP - 670

EP - 672

JO - Experimental and Clinical Transplantation

JF - Experimental and Clinical Transplantation

SN - 1304-0855

IS - 2

ER -