Calcium enhances Salmonella typhimurium invasion of HeLa cells

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Salmonella typhimurium cultured with physiological levels of calcium are significantly enhanced in their ability to penetrate HeLa cells in vitro. Increased infectivity was not observed in magnesium-supplemented media, but was demonstrated in calcium-supplemented minimal defined or calcium-supplemented cation-deficient media. Invasion enhancement was observed for a number of S. typhimurium strains and ranged from 28-390% over calcium-deficient controls. Enhanced HeLa cell infectivity was not dependent on the presence of an autonomous 60-MDa plasmid.

Original languageEnglish (US)
Pages (from-to)299-304
Number of pages6
JournalFEMS Microbiology Letters
Volume41
Issue number3
StatePublished - 1987

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Salmonella typhimurium
HeLa Cells
Calcium
Magnesium
Cations
Plasmids

Keywords

  • Calcium
  • HeLa cell invasion
  • Salmonella typhimurium
  • Virulence

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Calcium enhances Salmonella typhimurium invasion of HeLa cells. / Niesel, David; Peterson, Johnny.

In: FEMS Microbiology Letters, Vol. 41, No. 3, 1987, p. 299-304.

Research output: Contribution to journalArticle

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