Calcium entry blockers increase interleukin-10 production in endotoxemia

Csaba Szabo, György Haskó, Zollán H. Németh, E. Sylvester Vizi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Intracellular calcium is an important mediator of the cellular response in endotoxemia and shock. Here we investigated the effects of verapamil and diltiazem, two calcium entry blockers, on endotoxin (bacterial lipopolysaccharide, LPS)-induced production of pro- and anti-inflammatory cytokines and of nitric oxide in mice. LPS-induced interleukin-10 plasma levels were significantly enhanced, and circulating tumor necrosis factor-α concentrations were significantly suppressed in animals pretreated intraperitoneally with verapamil (10 mg/kg) or diltiazem (20 mg/kg). However, LPS-induced interleukin-6 levels were unaffected by the calcium antagonists. Similarly, LPS-induced production of nitrite/nitrate (breakdown products of nitric oxide) was not affected by verapamil and diltiazem. We conclude that calcium entry blockers selectively modulate the production of some pro- and anti-inflammatory mediators in endotoxemia. These effects may contribute to the cytoprotective and anti-inflammatory effects of calcium entry blockers in shock and trauma.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalShock
Volume7
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Endotoxemia
Interleukin-10
Lipopolysaccharides
Diltiazem
Calcium
Verapamil
Anti-Inflammatory Agents
Shock
Nitric Oxide
Nitrites
Endotoxins
Nitrates
Interleukin-6
Tumor Necrosis Factor-alpha
Cytokines
Wounds and Injuries

ASJC Scopus subject areas

  • Physiology
  • Critical Care and Intensive Care Medicine

Cite this

Szabo, C., Haskó, G., Németh, Z. H., & Sylvester Vizi, E. (1997). Calcium entry blockers increase interleukin-10 production in endotoxemia. Shock, 7(4), 304-307.

Calcium entry blockers increase interleukin-10 production in endotoxemia. / Szabo, Csaba; Haskó, György; Németh, Zollán H.; Sylvester Vizi, E.

In: Shock, Vol. 7, No. 4, 1997, p. 304-307.

Research output: Contribution to journalArticle

Szabo, C, Haskó, G, Németh, ZH & Sylvester Vizi, E 1997, 'Calcium entry blockers increase interleukin-10 production in endotoxemia', Shock, vol. 7, no. 4, pp. 304-307.
Szabo C, Haskó G, Németh ZH, Sylvester Vizi E. Calcium entry blockers increase interleukin-10 production in endotoxemia. Shock. 1997;7(4):304-307.
Szabo, Csaba ; Haskó, György ; Németh, Zollán H. ; Sylvester Vizi, E. / Calcium entry blockers increase interleukin-10 production in endotoxemia. In: Shock. 1997 ; Vol. 7, No. 4. pp. 304-307.
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