Calcium modification techniques in complex percutaneous coronary intervention: State-of-the-art review

Brett M. Montelaro; Travis M. Wilson; Noah Newman; Edward “Trey” Woods; Muzamil Khawaja; Hafeez Hassan Virk; Johao Escobar; Mahboob Alam; Hani Jneid; Samin K. Sharma; Chayakrit Krittanawong

doi:10.1016/j.tcm.2025.04.004

Calcium modification techniques in complex percutaneous coronary intervention: State-of-the-art review

Brett M. Montelaro
, Travis M. Wilson
, Noah Newman
, Edward “Trey” Woods
, Muzamil Khawaja
, Hafeez Hassan Virk
, Johao Escobar
, Mahboob Alam
, Hani Jneid
, Samin K. Sharma
, Chayakrit Krittanawong

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

As patients increase in age and medical complexity, coronary artery calcification is frequently encountered and its presence portends worse outcomes following percutaneous coronary intervention (PCI) - negatively impacting procedural success and long-term outcomes. This review paper explores available imaging techniques and calcium modification technique that can identify, characterize and modify these lesions to facilitate stent implantation. The data supporting these techniques are explored and an algorithm for decision-making during lesion modification is presented. Current barriers and future directions are additionally discussed.

Original language	English (US)
Pages (from-to)	430-439
Number of pages	10
Journal	Trends in Cardiovascular Medicine
Volume	35
Issue number	7
DOIs	https://doi.org/10.1016/j.tcm.2025.04.004
State	Published - Oct 2025

Keywords

Complex percutaneous coronary intervention
Coronary artery calcification modification
Intravascular imaging

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.tcm.2025.04.004

Cite this

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title = "Calcium modification techniques in complex percutaneous coronary intervention: State-of-the-art review",

abstract = "As patients increase in age and medical complexity, coronary artery calcification is frequently encountered and its presence portends worse outcomes following percutaneous coronary intervention (PCI) - negatively impacting procedural success and long-term outcomes. This review paper explores available imaging techniques and calcium modification technique that can identify, characterize and modify these lesions to facilitate stent implantation. The data supporting these techniques are explored and an algorithm for decision-making during lesion modification is presented. Current barriers and future directions are additionally discussed.",

keywords = "Complex percutaneous coronary intervention, Coronary artery calcification modification, Intravascular imaging",

author = "Montelaro, \{Brett M.\} and Wilson, \{Travis M.\} and Noah Newman and Woods, \{Edward “Trey”\} and Muzamil Khawaja and Virk, \{Hafeez Hassan\} and Johao Escobar and Mahboob Alam and Hani Jneid and Sharma, \{Samin K.\} and Chayakrit Krittanawong",

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year = "2025",

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doi = "10.1016/j.tcm.2025.04.004",

language = "English (US)",

volume = "35",

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TY - JOUR

T1 - Calcium modification techniques in complex percutaneous coronary intervention

T2 - State-of-the-art review

AU - Montelaro, Brett M.

AU - Wilson, Travis M.

AU - Newman, Noah

AU - Woods, Edward “Trey”

AU - Khawaja, Muzamil

AU - Virk, Hafeez Hassan

AU - Escobar, Johao

AU - Alam, Mahboob

AU - Jneid, Hani

AU - Sharma, Samin K.

AU - Krittanawong, Chayakrit

PY - 2025/10

Y1 - 2025/10

N2 - As patients increase in age and medical complexity, coronary artery calcification is frequently encountered and its presence portends worse outcomes following percutaneous coronary intervention (PCI) - negatively impacting procedural success and long-term outcomes. This review paper explores available imaging techniques and calcium modification technique that can identify, characterize and modify these lesions to facilitate stent implantation. The data supporting these techniques are explored and an algorithm for decision-making during lesion modification is presented. Current barriers and future directions are additionally discussed.

AB - As patients increase in age and medical complexity, coronary artery calcification is frequently encountered and its presence portends worse outcomes following percutaneous coronary intervention (PCI) - negatively impacting procedural success and long-term outcomes. This review paper explores available imaging techniques and calcium modification technique that can identify, characterize and modify these lesions to facilitate stent implantation. The data supporting these techniques are explored and an algorithm for decision-making during lesion modification is presented. Current barriers and future directions are additionally discussed.

KW - Complex percutaneous coronary intervention

KW - Coronary artery calcification modification

KW - Intravascular imaging

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DO - 10.1016/j.tcm.2025.04.004

M3 - Review article

C2 - 40311770

AN - SCOPUS:105004922670

SN - 1050-1738

VL - 35

SP - 430

EP - 439

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 7

ER -

Calcium modification techniques in complex percutaneous coronary intervention: State-of-the-art review

Abstract

Keywords

ASJC Scopus subject areas

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