Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma

Michael J. Wargovich, Gerald Isbell, Joseph Shabot, Rodger Winn, Frank Lanza, Lyone Hochman, Ellen Larson, Patrick Lynch, Leor Roubein, Bernard Levin

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Abstract

The results of three small clinical trials examining the effect of calcium carbonate supplementation on the proliferation cytokinetics of the rectal epithelium in subjects with a current history of sporadic adenoma are reported. In six subjects, a daily administration of 1500 mg of calcium carbonate for 90 days failed to significantly suppress thymidine labeling in normal-appearing mucosa of the rectum. However, a daily dose of 2000 mg of calcium significantly (P = 0.008) altered mucosal proliferation in a second set of six subjects after a 30-day trial. Finally, a placebo-controlled trial of calcium (2000 mg) was conducted in which 20 subjects were randomized to groups receiving a 4-week intervention with calcium (or placebo), followed by the alternative treatment (placebo or calcium). The results of the study show a marked suppression of rectal proliferation during the calcium phase of the study but not during the placebo phase. This study adds to accumulating evidence showing that calcium supplementation regulates the proliferative behavior of colonic epithelium in the individual at high risk for colon cancer. Longer term trials of calcium supplementation will ascertain whether a continuing benefit from increasing dietary calcium translates into inhibition of adenoma recurrence.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalGastroenterology
Volume103
Issue number1
StatePublished - 1992

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Adenoma
Epithelial Cells
Cell Proliferation
Calcium
Placebos
Calcium Carbonate
Epithelium
Dietary Calcium
Rectum
Colonic Neoplasms
Thymidine
Mucous Membrane
Clinical Trials
Recurrence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Wargovich, M. J., Isbell, G., Shabot, J., Winn, R., Lanza, F., Hochman, L., ... Levin, B. (1992). Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma. Gastroenterology, 103(1), 92-97.

Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma. / Wargovich, Michael J.; Isbell, Gerald; Shabot, Joseph; Winn, Rodger; Lanza, Frank; Hochman, Lyone; Larson, Ellen; Lynch, Patrick; Roubein, Leor; Levin, Bernard.

In: Gastroenterology, Vol. 103, No. 1, 1992, p. 92-97.

Research output: Contribution to journalArticle

Wargovich, MJ, Isbell, G, Shabot, J, Winn, R, Lanza, F, Hochman, L, Larson, E, Lynch, P, Roubein, L & Levin, B 1992, 'Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma', Gastroenterology, vol. 103, no. 1, pp. 92-97.
Wargovich, Michael J. ; Isbell, Gerald ; Shabot, Joseph ; Winn, Rodger ; Lanza, Frank ; Hochman, Lyone ; Larson, Ellen ; Lynch, Patrick ; Roubein, Leor ; Levin, Bernard. / Calcium supplementation decreases rectal epithelial cell proliferation in subjects with sporadic adenoma. In: Gastroenterology. 1992 ; Vol. 103, No. 1. pp. 92-97.
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