California group arboviruses. Electron microscopic studies

Frederick A. Murphy, Sylvia G. Whitfield, Philip H. Coleman, Charles H. Calisher, Erwin R. Rabin, A. Bennett Jenson, Joseph L. Melnick, Mercedes R. Edwards, Elinor Whitney

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.

Original languageEnglish (US)
Pages (from-to)44-56
Number of pages13
JournalExperimental and Molecular Pathology
Volume9
Issue number1
StatePublished - Aug 1968

Fingerprint

Arboviruses
Viruses
Electrons
Virion
Extracellular Space
Organelles
Edema
Cytoplasm
Cell Culture Techniques
Neurons
Membranes
Cell culture
Infiltration
Brain
Microscopic examination

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Murphy, F. A., Whitfield, S. G., Coleman, P. H., Calisher, C. H., Rabin, E. R., Bennett Jenson, A., ... Whitney, E. (1968). California group arboviruses. Electron microscopic studies. Experimental and Molecular Pathology, 9(1), 44-56.

California group arboviruses. Electron microscopic studies. / Murphy, Frederick A.; Whitfield, Sylvia G.; Coleman, Philip H.; Calisher, Charles H.; Rabin, Erwin R.; Bennett Jenson, A.; Melnick, Joseph L.; Edwards, Mercedes R.; Whitney, Elinor.

In: Experimental and Molecular Pathology, Vol. 9, No. 1, 08.1968, p. 44-56.

Research output: Contribution to journalArticle

Murphy, FA, Whitfield, SG, Coleman, PH, Calisher, CH, Rabin, ER, Bennett Jenson, A, Melnick, JL, Edwards, MR & Whitney, E 1968, 'California group arboviruses. Electron microscopic studies', Experimental and Molecular Pathology, vol. 9, no. 1, pp. 44-56.
Murphy FA, Whitfield SG, Coleman PH, Calisher CH, Rabin ER, Bennett Jenson A et al. California group arboviruses. Electron microscopic studies. Experimental and Molecular Pathology. 1968 Aug;9(1):44-56.
Murphy, Frederick A. ; Whitfield, Sylvia G. ; Coleman, Philip H. ; Calisher, Charles H. ; Rabin, Erwin R. ; Bennett Jenson, A. ; Melnick, Joseph L. ; Edwards, Mercedes R. ; Whitney, Elinor. / California group arboviruses. Electron microscopic studies. In: Experimental and Molecular Pathology. 1968 ; Vol. 9, No. 1. pp. 44-56.
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