Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Clinical Biochemistry