California group arboviruses. Electron microscopic studies

Frederick A. Murphy, Sylvia G. Whitfield, Philip H. Coleman, Charles H. Calisher, Erwin R. Rabin, A. Bennett Jenson, Joseph L. Melnick, Mercedes R. Edwards, Elinor Whitney

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.

Original languageEnglish (US)
Pages (from-to)44-56
Number of pages13
JournalExperimental and Molecular Pathology
Volume9
Issue number1
DOIs
StatePublished - Aug 1968

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Murphy, F. A., Whitfield, S. G., Coleman, P. H., Calisher, C. H., Rabin, E. R., Bennett Jenson, A., Melnick, J. L., Edwards, M. R., & Whitney, E. (1968). California group arboviruses. Electron microscopic studies. Experimental and Molecular Pathology, 9(1), 44-56. https://doi.org/10.1016/0014-4800(68)90049-X