California group arboviruses. Electron microscopic studies

Frederick A. Murphy; Sylvia G. Whitfield; Philip H. Coleman; Charles H. Calisher; Erwin R. Rabin; A. Bennett Jenson; Joseph L. Melnick; Mercedes R. Edwards; Elinor Whitney

doi:10.1016/0014-4800(68)90049-X

California group arboviruses. Electron microscopic studies

Frederick A. Murphy
, Sylvia G. Whitfield
, Philip H. Coleman
, Charles H. Calisher
, Erwin R. Rabin
, A. Bennett Jenson
, Joseph L. Melnick
, Mercedes R. Edwards
, Elinor Whitney

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.

Original language	English (US)
Pages (from-to)	44-56
Number of pages	13
Journal	Experimental and Molecular Pathology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0014-4800(68)90049-X
State	Published - Aug 1968
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Clinical Biochemistry

Access to Document

10.1016/0014-4800(68)90049-X

Cite this

@article{1bc1dca66586496597af13e90ec36991,

title = "California group arboviruses. Electron microscopic studies",

abstract = "Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.",

author = "Murphy, \{Frederick A.\} and Whitfield, \{Sylvia G.\} and Coleman, \{Philip H.\} and Calisher, \{Charles H.\} and Rabin, \{Erwin R.\} and \{Bennett Jenson\}, A. and Melnick, \{Joseph L.\} and Edwards, \{Mercedes R.\} and Elinor Whitney",

year = "1968",

month = aug,

doi = "10.1016/0014-4800(68)90049-X",

language = "English (US)",

volume = "9",

pages = "44--56",

journal = "Experimental and Molecular Pathology",

issn = "0014-4800",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - California group arboviruses. Electron microscopic studies

AU - Murphy, Frederick A.

AU - Whitfield, Sylvia G.

AU - Coleman, Philip H.

AU - Calisher, Charles H.

AU - Rabin, Erwin R.

AU - Bennett Jenson, A.

AU - Melnick, Joseph L.

AU - Edwards, Mercedes R.

AU - Whitney, Elinor

PY - 1968/8

Y1 - 1968/8

N2 - Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.

AB - Electron microscopic examination of mouse brains infected with five California group arboviruses revealed similar changes consisting of perineuronal edema formation, minimal inflammatory cell infiltration and neuronal degeneration. Virus particles were observed in the cytoplasm of neurons in association with organelle membranes; particles were round or oval, with a moderately electron dense core surrounded by a ragged halo. Mean virus diameter was 98 mμ. Virus particles also accumulated in extracellular spaces. Similar virus morphology and cellular degeneration were observed in cell cultures infected with one of the viruses.

UR - https://www.scopus.com/pages/publications/0014315666

UR - https://www.scopus.com/pages/publications/0014315666#tab=citedBy

U2 - 10.1016/0014-4800(68)90049-X

DO - 10.1016/0014-4800(68)90049-X

M3 - Article

C2 - 4969997

AN - SCOPUS:0014315666

SN - 0014-4800

VL - 9

SP - 44

EP - 56

JO - Experimental and Molecular Pathology

JF - Experimental and Molecular Pathology

IS - 1

ER -

California group arboviruses. Electron microscopic studies

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this