Can fructose influence the development of obesity mediated through hypothalamic alterations?

Anderson Cargnin-Carvalho, Aline Haas de Mello, Joice Benedet Bressan, Kassiane Mathiola Backes, Marcela Fornari Uberti, Jéssica Benedet Fogaça, Cristini da Rosa Turatti, Eulla Keimili Fernandes Ferreira Cavalheiro, Thais Ceresér Vilela, Gislaine Tezza Rezin

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Epidemiological data from the last decades point to an exponential growth in the number of obese people. Different behavioral factors, mainly associated with food consumption, appear to contribute significantly to its development. Concomitant with increased obesity rates, an increase in the consumption of fructose has been observed; therefore, fructose consumption has been implicated as an important obesogenic factor. However, changes in brain activity due to fructose consumption are possible, especially in relation to hypothalamic satiety mechanisms. In addition, the obese state may provide an environment of chronic inflammation and further contribute to the discontinuation of satiety mechanisms in the hypothalamus. We briefly review the intrinsic alterations to the increased adipose tissue, its connections with the hypothalamus in the control of energy signaling mechanisms and, consequently, the participation of fructose as a co-adjuvant or trigger. Presenting the current context with clinical trials involving human and animal studies, we seek to contribute to a better understanding of the role of fructose in the progression of obesity.

Original languageEnglish (US)
Pages (from-to)1662-1668
Number of pages7
JournalJournal of Neuroscience Research
Issue number8
StatePublished - Aug 1 2020
Externally publishedYes


  • fructose
  • hypothalamus
  • metabolism
  • obesity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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