Can serum surfactant protein d or cc-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis?

Mona Elhaj, Julio Charles, Claudia Pedroza, Xiaochun Liu, Xiaodong Zhou, Rosa M. Estrada-Y-Martin, Emilio Gonzalez, Dorothy E. Lewis, Hilda T. Draeger, Sarah Kim, Frank C. Arnett, Maureen D. Mayes, Shervin Assassi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective. To examine the predictive significance of 2 pneumoproteins, surfactant protein D (SP-D) and CC-chemokine ligand 18 (CCL18), for the course of systemic sclerosis (SSc)-related interstitial lung disease. Methods. The pneumoproteins were determined in the baseline plasma samples of 266 patients with early SSc enrolled in the GENISOS observational cohort. They also were measured in 83 followup patient samples. Pulmonary function tests were obtained annually. The primary outcome was decline in forced vital capacity (FVC percentage predicted) over time. The predictive significance for longterm change in FVC was investigated by a joint analysis of longitudinal measurements (sequentially obtained FVC percentage predicted) and survival data. Results. SP-D and CCL18 levels were both higher in patients with SSc than in matched controls (p < 0.001 and p = 0.015, respectively). Baseline SP-D levels correlated with lower concomitantly obtained FVC (r = -0.27, p < 0.001), but did not predict the short-term decline in FVC at 1 year followup visit or its longterm decline rate. CCL18 showed a significant correlation with steeper short-term decline in FVC (p = 0.049), but was not a predictor of its longterm decline rate. Similarly, a composite score of SP-D and CCL18 was a significant predictor of short-term decline in FVC but did not predict its longterm decline rate. Further, the longitudinal change in these 2 pneumoproteins did not correlate with the concomitant percentage change in FVC. Conclusion. SP-D correlated with concomitantly obtained FVC, while CCL18 was a predictor of short-term decline in FVC. However, neither SP-D nor CCL18 was a longterm predictor of FVC course in patients with early SSc.

Original languageEnglish (US)
Pages (from-to)1114-1120
Number of pages7
JournalJournal of Rheumatology
Volume40
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Pulmonary Surfactant-Associated Protein D
CC Chemokines
Systemic Scleroderma
Interstitial Lung Diseases
Chemokines
Surface-Active Agents
Blood Proteins
Ligands
Respiratory Function Tests
Vital Capacity
Survival

Keywords

  • Cc-Chemokine Ligand 18
  • Interstitial Lung Disease
  • Surfactant D
  • Systemic Sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Can serum surfactant protein d or cc-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis? / Elhaj, Mona; Charles, Julio; Pedroza, Claudia; Liu, Xiaochun; Zhou, Xiaodong; Estrada-Y-Martin, Rosa M.; Gonzalez, Emilio; Lewis, Dorothy E.; Draeger, Hilda T.; Kim, Sarah; Arnett, Frank C.; Mayes, Maureen D.; Assassi, Shervin.

In: Journal of Rheumatology, Vol. 40, No. 7, 07.2013, p. 1114-1120.

Research output: Contribution to journalArticle

Elhaj, M, Charles, J, Pedroza, C, Liu, X, Zhou, X, Estrada-Y-Martin, RM, Gonzalez, E, Lewis, DE, Draeger, HT, Kim, S, Arnett, FC, Mayes, MD & Assassi, S 2013, 'Can serum surfactant protein d or cc-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis?', Journal of Rheumatology, vol. 40, no. 7, pp. 1114-1120. https://doi.org/10.3899/jrheum.120997
Elhaj, Mona ; Charles, Julio ; Pedroza, Claudia ; Liu, Xiaochun ; Zhou, Xiaodong ; Estrada-Y-Martin, Rosa M. ; Gonzalez, Emilio ; Lewis, Dorothy E. ; Draeger, Hilda T. ; Kim, Sarah ; Arnett, Frank C. ; Mayes, Maureen D. ; Assassi, Shervin. / Can serum surfactant protein d or cc-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis?. In: Journal of Rheumatology. 2013 ; Vol. 40, No. 7. pp. 1114-1120.
@article{1f834ea3affb4553ad05951ef886e162,
title = "Can serum surfactant protein d or cc-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis?",
abstract = "Objective. To examine the predictive significance of 2 pneumoproteins, surfactant protein D (SP-D) and CC-chemokine ligand 18 (CCL18), for the course of systemic sclerosis (SSc)-related interstitial lung disease. Methods. The pneumoproteins were determined in the baseline plasma samples of 266 patients with early SSc enrolled in the GENISOS observational cohort. They also were measured in 83 followup patient samples. Pulmonary function tests were obtained annually. The primary outcome was decline in forced vital capacity (FVC percentage predicted) over time. The predictive significance for longterm change in FVC was investigated by a joint analysis of longitudinal measurements (sequentially obtained FVC percentage predicted) and survival data. Results. SP-D and CCL18 levels were both higher in patients with SSc than in matched controls (p < 0.001 and p = 0.015, respectively). Baseline SP-D levels correlated with lower concomitantly obtained FVC (r = -0.27, p < 0.001), but did not predict the short-term decline in FVC at 1 year followup visit or its longterm decline rate. CCL18 showed a significant correlation with steeper short-term decline in FVC (p = 0.049), but was not a predictor of its longterm decline rate. Similarly, a composite score of SP-D and CCL18 was a significant predictor of short-term decline in FVC but did not predict its longterm decline rate. Further, the longitudinal change in these 2 pneumoproteins did not correlate with the concomitant percentage change in FVC. Conclusion. SP-D correlated with concomitantly obtained FVC, while CCL18 was a predictor of short-term decline in FVC. However, neither SP-D nor CCL18 was a longterm predictor of FVC course in patients with early SSc.",
keywords = "Cc-Chemokine Ligand 18, Interstitial Lung Disease, Surfactant D, Systemic Sclerosis",
author = "Mona Elhaj and Julio Charles and Claudia Pedroza and Xiaochun Liu and Xiaodong Zhou and Estrada-Y-Martin, {Rosa M.} and Emilio Gonzalez and Lewis, {Dorothy E.} and Draeger, {Hilda T.} and Sarah Kim and Arnett, {Frank C.} and Mayes, {Maureen D.} and Shervin Assassi",
year = "2013",
month = "7",
doi = "10.3899/jrheum.120997",
language = "English (US)",
volume = "40",
pages = "1114--1120",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "7",

}

TY - JOUR

T1 - Can serum surfactant protein d or cc-chemokine ligand 18 predict outcome of interstitial lung disease in patients with early systemic sclerosis?

AU - Elhaj, Mona

AU - Charles, Julio

AU - Pedroza, Claudia

AU - Liu, Xiaochun

AU - Zhou, Xiaodong

AU - Estrada-Y-Martin, Rosa M.

AU - Gonzalez, Emilio

AU - Lewis, Dorothy E.

AU - Draeger, Hilda T.

AU - Kim, Sarah

AU - Arnett, Frank C.

AU - Mayes, Maureen D.

AU - Assassi, Shervin

PY - 2013/7

Y1 - 2013/7

N2 - Objective. To examine the predictive significance of 2 pneumoproteins, surfactant protein D (SP-D) and CC-chemokine ligand 18 (CCL18), for the course of systemic sclerosis (SSc)-related interstitial lung disease. Methods. The pneumoproteins were determined in the baseline plasma samples of 266 patients with early SSc enrolled in the GENISOS observational cohort. They also were measured in 83 followup patient samples. Pulmonary function tests were obtained annually. The primary outcome was decline in forced vital capacity (FVC percentage predicted) over time. The predictive significance for longterm change in FVC was investigated by a joint analysis of longitudinal measurements (sequentially obtained FVC percentage predicted) and survival data. Results. SP-D and CCL18 levels were both higher in patients with SSc than in matched controls (p < 0.001 and p = 0.015, respectively). Baseline SP-D levels correlated with lower concomitantly obtained FVC (r = -0.27, p < 0.001), but did not predict the short-term decline in FVC at 1 year followup visit or its longterm decline rate. CCL18 showed a significant correlation with steeper short-term decline in FVC (p = 0.049), but was not a predictor of its longterm decline rate. Similarly, a composite score of SP-D and CCL18 was a significant predictor of short-term decline in FVC but did not predict its longterm decline rate. Further, the longitudinal change in these 2 pneumoproteins did not correlate with the concomitant percentage change in FVC. Conclusion. SP-D correlated with concomitantly obtained FVC, while CCL18 was a predictor of short-term decline in FVC. However, neither SP-D nor CCL18 was a longterm predictor of FVC course in patients with early SSc.

AB - Objective. To examine the predictive significance of 2 pneumoproteins, surfactant protein D (SP-D) and CC-chemokine ligand 18 (CCL18), for the course of systemic sclerosis (SSc)-related interstitial lung disease. Methods. The pneumoproteins were determined in the baseline plasma samples of 266 patients with early SSc enrolled in the GENISOS observational cohort. They also were measured in 83 followup patient samples. Pulmonary function tests were obtained annually. The primary outcome was decline in forced vital capacity (FVC percentage predicted) over time. The predictive significance for longterm change in FVC was investigated by a joint analysis of longitudinal measurements (sequentially obtained FVC percentage predicted) and survival data. Results. SP-D and CCL18 levels were both higher in patients with SSc than in matched controls (p < 0.001 and p = 0.015, respectively). Baseline SP-D levels correlated with lower concomitantly obtained FVC (r = -0.27, p < 0.001), but did not predict the short-term decline in FVC at 1 year followup visit or its longterm decline rate. CCL18 showed a significant correlation with steeper short-term decline in FVC (p = 0.049), but was not a predictor of its longterm decline rate. Similarly, a composite score of SP-D and CCL18 was a significant predictor of short-term decline in FVC but did not predict its longterm decline rate. Further, the longitudinal change in these 2 pneumoproteins did not correlate with the concomitant percentage change in FVC. Conclusion. SP-D correlated with concomitantly obtained FVC, while CCL18 was a predictor of short-term decline in FVC. However, neither SP-D nor CCL18 was a longterm predictor of FVC course in patients with early SSc.

KW - Cc-Chemokine Ligand 18

KW - Interstitial Lung Disease

KW - Surfactant D

KW - Systemic Sclerosis

UR - http://www.scopus.com/inward/record.url?scp=84879981373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879981373&partnerID=8YFLogxK

U2 - 10.3899/jrheum.120997

DO - 10.3899/jrheum.120997

M3 - Article

VL - 40

SP - 1114

EP - 1120

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 7

ER -