Can statins reduce the inflammatory response associated with preterm birth in an animal model?

Sanmaan K. Basraon, Ramkumar Menon, Michel Makhlouf, Monica Longo, Gary D.V. Hankins, George R. Saade, Maged M. Costantine

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Objective: The objective of the study was to determine the effect of statins on lipopolysaccharide (LPS)-induced inflammatory response in a mouse model of preterm birth (PTB). Study Design: Day 15 CD1 mice were randomly allocated to intraperitoneal LPS injection (100 μg) or control. Mice in the LPS group were pretreated, 16 and 2 hours prior, with pravastatin (10 μg/g), simvastatin (10 μg/g), or vehicle control. Animals were sacrificed 6 hours after LPS. Cytokine messenger ribonucleic acid (mRNA) expression in the uterus and cervix, and concentrations in the maternal serum and amniotic fluid (AF) were determined. Results: Pravastatin reduced interleukin (IL)-1β and IL-6 mRNA expression in the uterus and cervix, respectively, and serum IL-1β and granulocyte-macrophage colony-stimulating factor (GM-CSF) concentrations. Simvastatin reduced IL-1β and IL-6 mRNA expressions in the uterus, IL-6 and tumor necrosis factor alpha (TNF-α) in the cervix, and IL-1β, IL-2, IL-12p70, IL-13, TNF-α, GM-CSF, and interferon-γ concentrations in the serum and IL-6 in AF. Conclusion: Statins reduce the LPS-induced inflammatory responses in a mouse model of PTB.

Original languageEnglish (US)
Pages (from-to)224.e1-224.e7
JournalAmerican journal of obstetrics and gynecology
Volume207
Issue number3
DOIs
StatePublished - Sep 2012

Keywords

  • cytokines
  • inflammation
  • preterm delivery
  • statins

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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