Canavan Disease

Reuben Matalon, Kimberlee Michals Matalon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Spongy degeneration of the brain, Canavan disease, is an autosomal recessive leukodystrophy prevalent among individuals of Ashkenazi Jewish extraction. The disease is characterized by severe mental retardation, developmental delays, and early death. Deficiency of the enzyme aspartoacylase, causes excessive amounts of N-acetylaspartic acid in the urine, brain and body fluids. High levels of N-acetylaspartic acid in the urine are diagnostic for Canavan disease. Mild or juvenile cases of Canavan disease with mild elevation of N-acetylaspartic acid and developmental delay have also been found. The gene for aspartoacylase has been cloned and mutations identified. Ashkenazi Jewish populations have two mutations in 98% of the cases while other ethnic groups have more diverse mutations. A knockout mouse with the same phenotype as Canavan disease has been generated. Trials in knockout mice and Canavan patients are underway for potential treatment for Canavan disease.

Original languageEnglish (US)
Title of host publicationRosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition
PublisherElsevier Inc.
Pages695-701
Number of pages7
ISBN (Print)9780124105294, 9780124105492
DOIs
StatePublished - Nov 13 2014

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Canavan Disease
Knockout Mice
Mutation
Urine
Brain Diseases
Body Fluids
Ethnic Groups
Intellectual Disability
Phenotype

Keywords

  • Aspartoacylase deficiency
  • Canavan Disease
  • Leukodystrophy
  • Spongy degeneration of the brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Matalon, R., & Matalon, K. M. (2014). Canavan Disease. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition (pp. 695-701). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-410529-4.00062-0

Canavan Disease. / Matalon, Reuben; Matalon, Kimberlee Michals.

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition. Elsevier Inc., 2014. p. 695-701.

Research output: Chapter in Book/Report/Conference proceedingChapter

Matalon, R & Matalon, KM 2014, Canavan Disease. in Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition. Elsevier Inc., pp. 695-701. https://doi.org/10.1016/B978-0-12-410529-4.00062-0
Matalon R, Matalon KM. Canavan Disease. In Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition. Elsevier Inc. 2014. p. 695-701 https://doi.org/10.1016/B978-0-12-410529-4.00062-0
Matalon, Reuben ; Matalon, Kimberlee Michals. / Canavan Disease. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition. Elsevier Inc., 2014. pp. 695-701
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