Cancer cachexia and anabolic interventions

A case report

Edgar Dillon, Gurjot Basra, Astrid M. Horstman, Shanon L. Casperson, Kathleen M. Randolph, William J. Durham, Randall Urban, Concepcion Diaz-Arrastia, Lyuba Levine, Sandra Hatch, Maurice Willis, Gwyn Richardson, Melinda Sheffield-Moore

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Standard-of-care (SOC) cancer treatments are primarily aimed at reducing size and progression of a tumor. There is a need for successful supplemental anabolic therapies to combat cancer cachexia in addition to these SOC treatment modalities. Anabolic interventions, including testosterone and amino acid supplements, may be beneficial in reducing and/or reversing muscle wasting in these patient populations. Methods: A 48-year-old Caucasian female with recurrent cervical cancer was scheduled to receive three 21-day cycles of cisplatin and topetecan chemotherapy. She qualified, consented, and enrolled into a blinded interventional pilot study where she received daily whey protein (10 g, three times per day with meals) and a weekly injection of testosterone enanthate (100 mg intramuscular) before and during the SOC chemotherapy treatment period. Body composition, serum inflammatory markers, mixed muscle protein synthesis and breakdown rates, physical function, fatigue, and quality of life were assessed before and after the intervention period. Results: Body composition, as assessed by an increase in body weight and lean body mass and reduction in fat mass; physical function; fatigue; and quality of life each improved across the entire intervention period despite general increases in inflammatory markers and no improvements in muscle protein turnover towards the end of the intervention. Conclusions: Concomitant treatment of oral amino acids and testosterone may be a viable therapeutic option for fighting cachexia and improving body composition and quality of life during chemotherapeutic treatment of recurrent cervical cancer. These positive outcomes may be attainable over time despite overall poor inflammatory status.

Original languageEnglish (US)
Pages (from-to)253-263
Number of pages11
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume3
Issue number4
DOIs
StatePublished - 2012

Fingerprint

Cachexia
Standard of Care
Body Composition
Neoplasms
Muscle Proteins
Quality of Life
Uterine Cervical Neoplasms
Therapeutics
Fatigue
Testosterone
Amino Acids
Drug Therapy
Cisplatin
Meals
Biomarkers
Fats
Body Weight
Muscles
Injections
Population

Keywords

  • Amino acids
  • Cervical cancer
  • Fatigue
  • Lean body mass
  • Quality of life
  • Testosterone

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physiology (medical)

Cite this

Dillon, E., Basra, G., Horstman, A. M., Casperson, S. L., Randolph, K. M., Durham, W. J., ... Sheffield-Moore, M. (2012). Cancer cachexia and anabolic interventions: A case report. Journal of Cachexia, Sarcopenia and Muscle, 3(4), 253-263. https://doi.org/10.1007/s13539-012-0066-6

Cancer cachexia and anabolic interventions : A case report. / Dillon, Edgar; Basra, Gurjot; Horstman, Astrid M.; Casperson, Shanon L.; Randolph, Kathleen M.; Durham, William J.; Urban, Randall; Diaz-Arrastia, Concepcion; Levine, Lyuba; Hatch, Sandra; Willis, Maurice; Richardson, Gwyn; Sheffield-Moore, Melinda.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 3, No. 4, 2012, p. 253-263.

Research output: Contribution to journalArticle

Dillon, E, Basra, G, Horstman, AM, Casperson, SL, Randolph, KM, Durham, WJ, Urban, R, Diaz-Arrastia, C, Levine, L, Hatch, S, Willis, M, Richardson, G & Sheffield-Moore, M 2012, 'Cancer cachexia and anabolic interventions: A case report', Journal of Cachexia, Sarcopenia and Muscle, vol. 3, no. 4, pp. 253-263. https://doi.org/10.1007/s13539-012-0066-6
Dillon, Edgar ; Basra, Gurjot ; Horstman, Astrid M. ; Casperson, Shanon L. ; Randolph, Kathleen M. ; Durham, William J. ; Urban, Randall ; Diaz-Arrastia, Concepcion ; Levine, Lyuba ; Hatch, Sandra ; Willis, Maurice ; Richardson, Gwyn ; Sheffield-Moore, Melinda. / Cancer cachexia and anabolic interventions : A case report. In: Journal of Cachexia, Sarcopenia and Muscle. 2012 ; Vol. 3, No. 4. pp. 253-263.
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