Cancer of the gallbladder in Bolivia

Suggestions concerning etiology

J. Rios-Dalenz, A. Takabayashi, D. E. Henson, B. L. Strom, R. D. Soloway

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In order to investigate the very high incidence of gallbladder cancer in Bolivia, a series of patients with gallbladder cancer and/or cholelithiasis from a hospital in La Paz was compared to a series of patients with cholelithiasis from Philadelphia. Each group demonstrated a similar female predilection. Bolivian patients with gallbladder cancer were older than patients with cholelithiasis who, in turn, were older than the general population (p < 0.001). Racial differences demonstrated previously were confirmed. Bolivian gallstones were uniformly cholesterol in type, in contrast to the US series, in which 27% of patients had black pigment stones. Bile specimens obtained from Bolivian patients with cholelithiasis had a lower concentration of bile salts, phospholipids, and cholesterol than bile specimens from US cholelithiasis patients (p < 0.01, < 0.001, and < 0.001, respectively). These biochemical differences may help to explain the differing incidence of cholelithiasis and gallbladder cancer in the US and Bolivia.

Original languageEnglish (US)
Pages (from-to)371-375
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume80
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

Bolivia
Gallbladder Neoplasms
Cholelithiasis
Bile
Cholesterol
Incidence
Gallstones
Bile Acids and Salts
Phospholipids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Rios-Dalenz, J., Takabayashi, A., Henson, D. E., Strom, B. L., & Soloway, R. D. (1985). Cancer of the gallbladder in Bolivia: Suggestions concerning etiology. American Journal of Gastroenterology, 80(5), 371-375.

Cancer of the gallbladder in Bolivia : Suggestions concerning etiology. / Rios-Dalenz, J.; Takabayashi, A.; Henson, D. E.; Strom, B. L.; Soloway, R. D.

In: American Journal of Gastroenterology, Vol. 80, No. 5, 1985, p. 371-375.

Research output: Contribution to journalArticle

Rios-Dalenz, J, Takabayashi, A, Henson, DE, Strom, BL & Soloway, RD 1985, 'Cancer of the gallbladder in Bolivia: Suggestions concerning etiology', American Journal of Gastroenterology, vol. 80, no. 5, pp. 371-375.
Rios-Dalenz J, Takabayashi A, Henson DE, Strom BL, Soloway RD. Cancer of the gallbladder in Bolivia: Suggestions concerning etiology. American Journal of Gastroenterology. 1985;80(5):371-375.
Rios-Dalenz, J. ; Takabayashi, A. ; Henson, D. E. ; Strom, B. L. ; Soloway, R. D. / Cancer of the gallbladder in Bolivia : Suggestions concerning etiology. In: American Journal of Gastroenterology. 1985 ; Vol. 80, No. 5. pp. 371-375.
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