Cancer of the Gallbladder in Bolivia: Suggestions Concerning Etiology

Jaime Rios‐Dalenz, Arimichi Takabayashi, Donald E. Henson, Brian L. Strom, Roger D. Soloway

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

In order to investigate the very high incidence of gallbladder cancer in Bolivia, a series of patients with gallbladder cancer and/or cholelithiasis from a hospital in La Paz was compared to a series of patients with cholelithiasis from Philadelphia. Each group demonstrated a similar female predilection. Bolivian patients with gallbladder cancer were older than patients with cholelithiasis who, in turn, were older than the general population (p < 0.001). Racial differences demonstrated previously were confirmed. Bolivian gallstones were uniformly cholesterol in type, in contrast to the US series, in which 27% of patients had black pigment stones. Bile specimens obtained from Bolivian patients with cholelithiasis had a lower concentration of bile salts, phospholipids, and cholesterol than bile specimens from US cholelithiasis patients (p < 0.01, < 0.001, and < 0.001, respectively). These biochemical differences may help to explain the differing incidence of cholelithiasis and gallbladder cancer in the US and Bolivia.

Original languageEnglish (US)
Pages (from-to)371-375
Number of pages5
JournalThe American Journal of Gastroenterology
Volume80
Issue number5
DOIs
StatePublished - May 1985

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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