Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study

Terence M. Myckatyn, I. Janelle Wagner, Babak J. Mehrara, Melissa A. Crosby, Julie Park, Bahjat F. Qaqish, Dominic T. Moore, Evan L. Busch, Amanda K. Silva, Surinder Kaur, David W. Ollila, Clara N. Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Fat transfer is an increasingly popular method for refining postmastectomy breast reconstructions. However, concern persists that fat transfer may promote disease recurrence. Adipocytes are derived from adipose-derived stem cells and express adipocytokines that can facilitate active breast cancer cells in laboratory models. The authors sought to evaluate the association between fat transfer to the reconstructed breast and cancer recurrence in patients diagnosed with local or regional invasive breast cancers. Methods: A multicenter, case-cohort study was performed. Eligible patients from four centers (Memorial Sloan Kettering, M. D. Anderson Cancer Center, Alvin J. Siteman Cancer Center, and the University of Chicago) were identified by each site's institutional tumor registry or cancer data warehouse. Eligibility criteria were as follows: mastectomy with immediate breast reconstruction between 2006 and 2011, age older than 21 years, female sex, and incident diagnosis of invasive ductal carcinoma (stage I, II, or III). Cases consisted of all recurrences during the study period, and controls consisted of a 30 percent random sample of the study population. Cox proportional hazards regression was used to evaluate for association between fat transfer and time to recurrence in bivariate and multivariate models. Results: The time to disease recurrence unadjusted hazard ratio for fat transfer was 0.99 (95 percent CI, 0.56 to 1.7). After adjustment for age, body mass index, stage, HER2/Neu receptor status, and estrogen receptor status, the hazard ratio was 0.97 (95 percent CI, 0.54 to 1.8). Conclusion: In this population of breast cancer patients who had mastectomy with immediate reconstruction, fat transfer was not associated with a higher risk of cancer recurrence.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalPlastic and Reconstructive Surgery
Volume139
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Cohort Studies
Fats
Recurrence
Breast Neoplasms
Neoplasms
Mammaplasty
Mastectomy
ErbB-2 Receptor
Ductal Carcinoma
Adipokines
Adipocytes
Estrogen Receptors
Population
Registries
Body Mass Index
Stem Cells

ASJC Scopus subject areas

  • Surgery

Cite this

Myckatyn, T. M., Wagner, I. J., Mehrara, B. J., Crosby, M. A., Park, J., Qaqish, B. F., ... Lee, C. N. (2017). Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study. Plastic and Reconstructive Surgery, 139(1), 11-18. https://doi.org/10.1097/PRS.0000000000002838

Cancer Risk after Fat Transfer : A Multicenter Case-Cohort Study. / Myckatyn, Terence M.; Wagner, I. Janelle; Mehrara, Babak J.; Crosby, Melissa A.; Park, Julie; Qaqish, Bahjat F.; Moore, Dominic T.; Busch, Evan L.; Silva, Amanda K.; Kaur, Surinder; Ollila, David W.; Lee, Clara N.

In: Plastic and Reconstructive Surgery, Vol. 139, No. 1, 01.01.2017, p. 11-18.

Research output: Contribution to journalArticle

Myckatyn, TM, Wagner, IJ, Mehrara, BJ, Crosby, MA, Park, J, Qaqish, BF, Moore, DT, Busch, EL, Silva, AK, Kaur, S, Ollila, DW & Lee, CN 2017, 'Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study', Plastic and Reconstructive Surgery, vol. 139, no. 1, pp. 11-18. https://doi.org/10.1097/PRS.0000000000002838
Myckatyn, Terence M. ; Wagner, I. Janelle ; Mehrara, Babak J. ; Crosby, Melissa A. ; Park, Julie ; Qaqish, Bahjat F. ; Moore, Dominic T. ; Busch, Evan L. ; Silva, Amanda K. ; Kaur, Surinder ; Ollila, David W. ; Lee, Clara N. / Cancer Risk after Fat Transfer : A Multicenter Case-Cohort Study. In: Plastic and Reconstructive Surgery. 2017 ; Vol. 139, No. 1. pp. 11-18.
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abstract = "Background: Fat transfer is an increasingly popular method for refining postmastectomy breast reconstructions. However, concern persists that fat transfer may promote disease recurrence. Adipocytes are derived from adipose-derived stem cells and express adipocytokines that can facilitate active breast cancer cells in laboratory models. The authors sought to evaluate the association between fat transfer to the reconstructed breast and cancer recurrence in patients diagnosed with local or regional invasive breast cancers. Methods: A multicenter, case-cohort study was performed. Eligible patients from four centers (Memorial Sloan Kettering, M. D. Anderson Cancer Center, Alvin J. Siteman Cancer Center, and the University of Chicago) were identified by each site's institutional tumor registry or cancer data warehouse. Eligibility criteria were as follows: mastectomy with immediate breast reconstruction between 2006 and 2011, age older than 21 years, female sex, and incident diagnosis of invasive ductal carcinoma (stage I, II, or III). Cases consisted of all recurrences during the study period, and controls consisted of a 30 percent random sample of the study population. Cox proportional hazards regression was used to evaluate for association between fat transfer and time to recurrence in bivariate and multivariate models. Results: The time to disease recurrence unadjusted hazard ratio for fat transfer was 0.99 (95 percent CI, 0.56 to 1.7). After adjustment for age, body mass index, stage, HER2/Neu receptor status, and estrogen receptor status, the hazard ratio was 0.97 (95 percent CI, 0.54 to 1.8). Conclusion: In this population of breast cancer patients who had mastectomy with immediate reconstruction, fat transfer was not associated with a higher risk of cancer recurrence.",
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AU - Park, Julie

AU - Qaqish, Bahjat F.

AU - Moore, Dominic T.

AU - Busch, Evan L.

AU - Silva, Amanda K.

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AU - Ollila, David W.

AU - Lee, Clara N.

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