Candida infection with and without nystatin prophylaxis: An 11-year experience with patients with burn injury

M. H. Desai, R. L. Rutan, J. P. Heggers, David Herndon

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The incidence of opportunistic infections after thermal injury is high. Since 1985, we have been practicing Candida prophylaxis using nystatin ''swish-and-swallow'' and topical therapy. Patients treated between 1980 and 1984 served as controls and received no Candida prophylaxis. Although mean burn size, full-thickness injury, and age were comparable, the incidence of Candida colonization (26.7% vs 15.6%), infection (21.3% vs 10.0%), and sepsis (12.2% vs none) was significantly different between control and nystatin-treated groups, respectively. With prophylaxis, the incidence of Candida wound infection has been significantly reduced, and systemic candidiasis has been eradicated, eliminating the need for toxic systemic antifungal agents.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalArchives of Surgery
Volume127
Issue number2
StatePublished - 1992

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Nystatin
Candida
Wounds and Injuries
Infection
Incidence
Swallows
Antifungal Agents
Poisons
Opportunistic Infections
Wound Infection
Deglutition
Sepsis
Hot Temperature
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Desai, M. H., Rutan, R. L., Heggers, J. P., & Herndon, D. (1992). Candida infection with and without nystatin prophylaxis: An 11-year experience with patients with burn injury. Archives of Surgery, 127(2), 159-162.

Candida infection with and without nystatin prophylaxis : An 11-year experience with patients with burn injury. / Desai, M. H.; Rutan, R. L.; Heggers, J. P.; Herndon, David.

In: Archives of Surgery, Vol. 127, No. 2, 1992, p. 159-162.

Research output: Contribution to journalArticle

Desai, MH, Rutan, RL, Heggers, JP & Herndon, D 1992, 'Candida infection with and without nystatin prophylaxis: An 11-year experience with patients with burn injury', Archives of Surgery, vol. 127, no. 2, pp. 159-162.
Desai, M. H. ; Rutan, R. L. ; Heggers, J. P. ; Herndon, David. / Candida infection with and without nystatin prophylaxis : An 11-year experience with patients with burn injury. In: Archives of Surgery. 1992 ; Vol. 127, No. 2. pp. 159-162.
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