Candida Infection With and Without Nystatin Prophylaxis: An 11-Year Experience With Patients With Burn Injury

Manu H. Desai, Randi L. Rutan, John P. Heggers, David N. Herndon

Research output: Contribution to journalArticle

52 Scopus citations


The incidence of opportunistic infections after thermal injury is high. Since 1985, we have been practicing Candida prophylaxis using nystatin “swish-and-swallow” and topical therapy. Patients treated between 1980 and 1984 served as controls and received no Candida prophylaxis. Although mean burn size, full-thickness injury, and age were comparable, the incidence of Candida colonization (26.7% vs 15.6%), infection (21.3% vs 10.0%), and sepsis (12.2% vs none) was significantly different between control and nystatin-treated groups, respectively. With prophylaxis, the incidence of Candida wound infection has been significantly reduced, and systemic candidiasis has been eradicated, eliminating the need for toxic systemic antifungal agents.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalArchives of Surgery
Issue number2
StatePublished - Feb 1992


ASJC Scopus subject areas

  • Surgery

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