Canine haptoglobin: A unique haptoglobin subunit arrangement

Alexander Kurosky, Regine E. Hay, Barbara H. Bowman

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


1. 1. Isolated canine haptoglobin behaved identically to the α2β2 structure typical of human haptoglobin type 1-1 on alkaline polyacrylamide gel electrophoresis and on gel filtration. 2. 2. In the presence of urea or sodium dodecyl sulphate canine haptoglobin dissociated into αβ subunits that separated into α and β chains after reduction with 2-mercaptoethanol. 3. 3. Compositional analysis identified one less half-cystine in canine α chain when compared to human α1 chain. 4. 4. These results provide evidence that there is no inter α chain disulphide in canine haptoglobin comparable to the α120-α120 disulphide in human haptoglobin that links the two αβ subunits.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Issue number4
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Biochemistry
  • Physiology


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