Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female c57bl6 mice

Sara Jane Ward, Michael David Ramirez, Harshini Neelakantan, Ellen Ann Walker

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The taxane chemotherapeutic paclitaxel frequently produces peripheral neuropathy in humans. Rodent models to investigate mechanisms and treatments are largely restricted to male rats, whereas female mouse studies are lacking. We characterized a range of paclitaxel doses on cold and mechanical allodynia in male and female C57Bl/6 mice. Because the nonpsychoactive phytocannabinoid cannabidiol attenuates other forms of neuropathic pain, we assessed its effect on paclitaxel-induced allodynia. Paclitaxel produced allodynia that was largely dose independent and more robust in female mice, and this effect was prevented by treatment with cannabidiol. Our preliminary findings therefore indicate that cannabidiol may prevent the development of paclitaxel-induced allodynia in mice and therefore be effective at preventing dose-limiting paclitaxel-induced peripheral neuropathy in humans.

Original languageEnglish (US)
Pages (from-to)947-950
Number of pages4
JournalAnesthesia and analgesia
Volume113
Issue number4
DOIs
StatePublished - Oct 2011

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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