Cannabinoid effects on plasma corticosterone and uptake of 3H-corticosterone by mouse brain

Kenneth M. Johnson; William L. Dewy; Katherine S. Ritter; Jacquieline S. Beckner

doi:10.1016/0014-2999(78)90238-8

Cannabinoid effects on plasma corticosterone and uptake of ³H-corticosterone by mouse brain

Kenneth M. Johnson, William L. Dewy, Katherine S. Ritter, Jacquieline S. Beckner

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The effects of three cannabinoids, 11-hyddroxy-Δ⁹-tetrahydracannabinol (11-OH-Δ⁹-THC), Δ⁹-THC and cannabinol (CBN), ranging in behavioral activity from high to low, were studied on two aspects of pituitary-adrenal function. Plasma corticosterone levels were used as an index of adrenocorticotropic hormone (ACTH) release. All three cannabinoids elicited an increase in plasma corticosterone levels in a mannger similr to their behavioral potency. These cannabinoids also elicited an increase in the concentration of ³H-corticosterone taken up by the brains of adrenalectomized mice in a mannger similar to their potency in elevating plasma corticosterone levels. The significance and possible underlying mechanism of the apparent correlation resulting between these effects and the behavioral effects of cannabionoids are discussed.

Original language	English (US)
Pages (from-to)	303-310
Number of pages	8
Journal	European Journal of Pharmacology
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(78)90238-8
State	Published - Feb 1 1978
Externally published	Yes

Keywords

Adrenocorticotropic hormone
Cannabinoids
Corticosteroids
Hippocampus
Structure-activity relationship

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(78)90238-8

Cite this

@article{8ff0d498d48a4496afd9db093116453f,

title = "Cannabinoid effects on plasma corticosterone and uptake of 3H-corticosterone by mouse brain",

abstract = "The effects of three cannabinoids, 11-hyddroxy-Δ9-tetrahydracannabinol (11-OH-Δ9-THC), Δ9-THC and cannabinol (CBN), ranging in behavioral activity from high to low, were studied on two aspects of pituitary-adrenal function. Plasma corticosterone levels were used as an index of adrenocorticotropic hormone (ACTH) release. All three cannabinoids elicited an increase in plasma corticosterone levels in a mannger similr to their behavioral potency. These cannabinoids also elicited an increase in the concentration of 3H-corticosterone taken up by the brains of adrenalectomized mice in a mannger similar to their potency in elevating plasma corticosterone levels. The significance and possible underlying mechanism of the apparent correlation resulting between these effects and the behavioral effects of cannabionoids are discussed.",

keywords = "Adrenocorticotropic hormone, Cannabinoids, Corticosteroids, Hippocampus, Structure-activity relationship",

author = "Johnson, {Kenneth M.} and Dewy, {William L.} and Ritter, {Katherine S.} and Beckner, {Jacquieline S.}",

note = "Funding Information: This researchw ass upported in part by U.S. Public Health Service Grants DA-00326, DA-00490 and F-32-DA-05012.",

year = "1978",

month = feb,

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doi = "10.1016/0014-2999(78)90238-8",

language = "English (US)",

volume = "47",

pages = "303--310",

journal = "European Journal of Pharmacology",

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AU - Johnson, Kenneth M.

AU - Dewy, William L.

AU - Ritter, Katherine S.

AU - Beckner, Jacquieline S.

N1 - Funding Information: This researchw ass upported in part by U.S. Public Health Service Grants DA-00326, DA-00490 and F-32-DA-05012.

PY - 1978/2/1

Y1 - 1978/2/1

N2 - The effects of three cannabinoids, 11-hyddroxy-Δ9-tetrahydracannabinol (11-OH-Δ9-THC), Δ9-THC and cannabinol (CBN), ranging in behavioral activity from high to low, were studied on two aspects of pituitary-adrenal function. Plasma corticosterone levels were used as an index of adrenocorticotropic hormone (ACTH) release. All three cannabinoids elicited an increase in plasma corticosterone levels in a mannger similr to their behavioral potency. These cannabinoids also elicited an increase in the concentration of 3H-corticosterone taken up by the brains of adrenalectomized mice in a mannger similar to their potency in elevating plasma corticosterone levels. The significance and possible underlying mechanism of the apparent correlation resulting between these effects and the behavioral effects of cannabionoids are discussed.

AB - The effects of three cannabinoids, 11-hyddroxy-Δ9-tetrahydracannabinol (11-OH-Δ9-THC), Δ9-THC and cannabinol (CBN), ranging in behavioral activity from high to low, were studied on two aspects of pituitary-adrenal function. Plasma corticosterone levels were used as an index of adrenocorticotropic hormone (ACTH) release. All three cannabinoids elicited an increase in plasma corticosterone levels in a mannger similr to their behavioral potency. These cannabinoids also elicited an increase in the concentration of 3H-corticosterone taken up by the brains of adrenalectomized mice in a mannger similar to their potency in elevating plasma corticosterone levels. The significance and possible underlying mechanism of the apparent correlation resulting between these effects and the behavioral effects of cannabionoids are discussed.

KW - Adrenocorticotropic hormone

KW - Cannabinoids

KW - Corticosteroids

KW - Hippocampus

KW - Structure-activity relationship

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