Canonical and non-canonical aryl hydrocarbon receptor signaling pathways

Eric J. Wright, Karen Pereira De Castro, Aditya D. Joshi, Cornelis Elferink

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Decades of research on the Aryl hydrocarbon Receptor (AhR) has unveiled its involvement in the toxicity of halogenated and polycyclic aromatic hydrocarbons, and a myriad of normal physiological processes. The molecular dissection of AhR biology has centered on a canonical signaling pathway in an effort to mechanistically reconcile the diverse pathophysiological effects of exposure to environmental pollutants. As a consequence, we now know that canonical signaling can explain many but not all of the AhR-mediated effects. Here we describe recent findings that point to non-canonical signaling pathways, and focus on a novel AhR interaction with the Krüppel-like Factor 6 protein responsible for previously unrecognized epigenetic changes in the chromatin affecting gene expression.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalCurrent Opinion in Toxicology
Volume2
DOIs
StatePublished - 2017

Fingerprint

Aryl Hydrocarbon Receptors
Physiological Phenomena
Dissection
Environmental Pollutants
Polycyclic Aromatic Hydrocarbons
Epigenomics
Gene expression
Chromatin
Toxicity
Gene Expression
Research
Proteins

ASJC Scopus subject areas

  • Toxicology

Cite this

Canonical and non-canonical aryl hydrocarbon receptor signaling pathways. / Wright, Eric J.; Pereira De Castro, Karen; Joshi, Aditya D.; Elferink, Cornelis.

In: Current Opinion in Toxicology, Vol. 2, 2017, p. 87-92.

Research output: Contribution to journalReview article

Wright, Eric J. ; Pereira De Castro, Karen ; Joshi, Aditya D. ; Elferink, Cornelis. / Canonical and non-canonical aryl hydrocarbon receptor signaling pathways. In: Current Opinion in Toxicology. 2017 ; Vol. 2. pp. 87-92.
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