Canonical and non-canonical aryl hydrocarbon receptor signaling pathways

Eric J. Wright, Karen Pereira De Castro, Aditya D. Joshi, Cornelis J. Elferink

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Decades of research on the Aryl hydrocarbon Receptor (AhR) has unveiled its involvement in the toxicity of halogenated and polycyclic aromatic hydrocarbons, and a myriad of normal physiological processes. The molecular dissection of AhR biology has centered on a canonical signaling pathway in an effort to mechanistically reconcile the diverse pathophysiological effects of exposure to environmental pollutants. As a consequence, we now know that canonical signaling can explain many but not all of the AhR-mediated effects. Here we describe recent findings that point to non-canonical signaling pathways, and focus on a novel AhR interaction with the Krüppel-like Factor 6 protein responsible for previously unrecognized epigenetic changes in the chromatin affecting gene expression.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalCurrent Opinion in Toxicology
Volume2
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Toxicology

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