Canonical and non-canonical aryl hydrocarbon receptor signaling pathways

Eric J. Wright, Karen Pereira De Castro, Aditya D. Joshi, Cornelis J. Elferink

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Decades of research on the Aryl hydrocarbon Receptor (AhR) has unveiled its involvement in the toxicity of halogenated and polycyclic aromatic hydrocarbons, and a myriad of normal physiological processes. The molecular dissection of AhR biology has centered on a canonical signaling pathway in an effort to mechanistically reconcile the diverse pathophysiological effects of exposure to environmental pollutants. As a consequence, we now know that canonical signaling can explain many but not all of the AhR-mediated effects. Here we describe recent findings that point to non-canonical signaling pathways, and focus on a novel AhR interaction with the Krüppel-like Factor 6 protein responsible for previously unrecognized epigenetic changes in the chromatin affecting gene expression.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalCurrent Opinion in Toxicology
Volume2
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Toxicology

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