Capsaicin-sensitive peptidergic neurons are involved in the Zosteriform spread of herpes simplex virus infection

L. R. Stanberry, Nigel Bourne, F. J. Bravo, D. I. Bernstein

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The intraneuronal transport of herpes simplex virus (HSV) is an essential component in disease pathogenesis. Capsaicin, a neuropharmacologic agent lacking direct antiviral activity, has been shown to protect animals against HSV-induced disease. It has been hypothesized that capsaicin acts by interfering with the intraneuronal transport of virus. Since animal models have been useful in studying the spread of virus, we used two guinea pig models of zosteriform herpes to examine the effect of capsaicin on HSV spread. Capsaicin was subcutaneously administered to Hartley guinea pigs prior to intravaginal or cutaneous HSV-2 inoculation. Treatment did not prevent the development of herpetic vesicles at the site of inoculation but significantly reduced the zosteriform spread of lesions in male and female animals. Further, after recovery from primary infection, capsaicin-treated male guinea pigs were observed to have fewer days with recurrent herpetic lesions. These results suggest that capsaicin-sensitive nerve fibers play a role in the pathologenesis of primary and recurrent HSV infections. Capsaicin appears to reduce the severity of cutaneous HSV infections by interfering with the spread of virus.

Original languageEnglish (US)
Pages (from-to)142-146
Number of pages5
JournalJournal of Medical Virology
Volume38
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Capsaicin
Herpes Zoster
Virus Diseases
Simplexvirus
Neurons
Guinea Pigs
Viruses
Skin
Human Herpesvirus 2
Nerve Fibers
Antiviral Agents
Animal Models
Infection

Keywords

  • Capsaicin
  • Guinea pig
  • Herpes simplex virus
  • Intraneuronal transport
  • Zosteriform spread

ASJC Scopus subject areas

  • Virology

Cite this

Capsaicin-sensitive peptidergic neurons are involved in the Zosteriform spread of herpes simplex virus infection. / Stanberry, L. R.; Bourne, Nigel; Bravo, F. J.; Bernstein, D. I.

In: Journal of Medical Virology, Vol. 38, No. 2, 1992, p. 142-146.

Research output: Contribution to journalArticle

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