Carbon monoxide and pulmonary circulation in an ovine model

J. L. Theissen, H. M. Loick, L. D. Traber, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The direct pulmonary vasoconstrictive effects of inhaled carbon monoxide were evaluated in chronically instrumented and anesthetized sheep (1.7% halothane in air) (n = 8). The response to carbon monoxide (2%), which was applied for 8 minutes through a double-lumen tube alternately to the left or right lung of each animal, was compared with baseline values. The induced carboxyhemoglobin level (65%) led to increases in cardiac output, pulmonary arterial pressure, stroke volume index, and heart rate. Systemic vascular resistance decreased, and pulmonary vascular resistance and mean arterial pressure were unchanged. The changes in pressure and flow were equivalent no matter which lung was exposed to carbon monoxide. No diversion of blood from one lung to the other was observed during the test period. We conclude that carbon monoxide does not have a direct pulmonary vasoconstrictive effect. The increase in pulmonary arterial pressure is a result of the decrease in mixed venous oxygen content (stimulus for hypoxic pulmonary vasoconstriction) and the increase in cardiac output.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalJournal of Burn Care and Rehabilitation
Volume13
Issue number6
StatePublished - 1992

Fingerprint

Pulmonary Circulation
Carbon Monoxide
Sheep
Lung
Arterial Pressure
Cardiac Output
Vascular Resistance
Carboxyhemoglobin
Halothane
Vasoconstriction
Stroke Volume
Heart Rate
Air
Oxygen
Pressure

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

Theissen, J. L., Loick, H. M., Traber, L. D., Herndon, D., & Traber, D. L. (1992). Carbon monoxide and pulmonary circulation in an ovine model. Journal of Burn Care and Rehabilitation, 13(6), 623-627.

Carbon monoxide and pulmonary circulation in an ovine model. / Theissen, J. L.; Loick, H. M.; Traber, L. D.; Herndon, David; Traber, D. L.

In: Journal of Burn Care and Rehabilitation, Vol. 13, No. 6, 1992, p. 623-627.

Research output: Contribution to journalArticle

Theissen, JL, Loick, HM, Traber, LD, Herndon, D & Traber, DL 1992, 'Carbon monoxide and pulmonary circulation in an ovine model', Journal of Burn Care and Rehabilitation, vol. 13, no. 6, pp. 623-627.
Theissen JL, Loick HM, Traber LD, Herndon D, Traber DL. Carbon monoxide and pulmonary circulation in an ovine model. Journal of Burn Care and Rehabilitation. 1992;13(6):623-627.
Theissen, J. L. ; Loick, H. M. ; Traber, L. D. ; Herndon, David ; Traber, D. L. / Carbon monoxide and pulmonary circulation in an ovine model. In: Journal of Burn Care and Rehabilitation. 1992 ; Vol. 13, No. 6. pp. 623-627.
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