Carcinoids of unknown origin

Comparative analysis with foregut, midgut, and hindgut carcinoids

P. M. Kirshbom, A. R. Kherani, M. W. Onaitis, J. M. Feldman, Douglas Tyler, E. C. Ellison

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background. Carcinoids are rare neuroendocrine tumors typically arising in the gastrointestinal tract. A significant percentage of these tumors present as metastatic disease of unknown primary site. The aim of this study was to better define the functional and clinical characteristics of carcinoids of unknown primary (CUP) site. Methods. This study examines the hormonal activity, clinical characteristics, and survival of 434 patients with carcinoids originating in the foregut, midgut, hindgut, or unknown location. The 143 patients with CUP were compared with the other groups with regard to presenting characteristics, diagnostic tests and therapeutic modalities used, hormonal activity, and survival. Results. The hormone levels (urinary 5-hydroxyindoleacetic acid and serotonin, serum and platelet serotonin) of CUP were not significantly different from midgut carcinoids with metastatic disease. Although survival with CUP was shorter than with carcinoids with identified primaries (10-year survivals of 22% vs 62%, 50%, and 48% for foregut, midgut, and hindgut, respectively), the survival curve for CUP was quite similar to that of patients with midgut carcinoids with distant disease (10-year survival of 22% vs 28%). Conclusions, CUP are similar to midgut carcinoids presenting with metastatic disease with regard to hormone production and survival. Like other carcinoids, CUP can be an indolent disease process with gradual progression over decades.

Original languageEnglish (US)
Pages (from-to)1063-1070
Number of pages8
JournalSurgery
Volume124
Issue number6
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Carcinoid Tumor
Survival
Serotonin
Hormones
Hydroxyindoleacetic Acid
Neuroendocrine Tumors
Routine Diagnostic Tests
Gastrointestinal Tract
Blood Platelets

ASJC Scopus subject areas

  • Surgery

Cite this

Kirshbom, P. M., Kherani, A. R., Onaitis, M. W., Feldman, J. M., Tyler, D., & Ellison, E. C. (1998). Carcinoids of unknown origin: Comparative analysis with foregut, midgut, and hindgut carcinoids. Surgery, 124(6), 1063-1070. https://doi.org/10.1067/msy.1998.93105

Carcinoids of unknown origin : Comparative analysis with foregut, midgut, and hindgut carcinoids. / Kirshbom, P. M.; Kherani, A. R.; Onaitis, M. W.; Feldman, J. M.; Tyler, Douglas; Ellison, E. C.

In: Surgery, Vol. 124, No. 6, 1998, p. 1063-1070.

Research output: Contribution to journalArticle

Kirshbom, PM, Kherani, AR, Onaitis, MW, Feldman, JM, Tyler, D & Ellison, EC 1998, 'Carcinoids of unknown origin: Comparative analysis with foregut, midgut, and hindgut carcinoids', Surgery, vol. 124, no. 6, pp. 1063-1070. https://doi.org/10.1067/msy.1998.93105
Kirshbom, P. M. ; Kherani, A. R. ; Onaitis, M. W. ; Feldman, J. M. ; Tyler, Douglas ; Ellison, E. C. / Carcinoids of unknown origin : Comparative analysis with foregut, midgut, and hindgut carcinoids. In: Surgery. 1998 ; Vol. 124, No. 6. pp. 1063-1070.
@article{a6ce50e48f8d4d0bb6528809d7d1ffb0,
title = "Carcinoids of unknown origin: Comparative analysis with foregut, midgut, and hindgut carcinoids",
abstract = "Background. Carcinoids are rare neuroendocrine tumors typically arising in the gastrointestinal tract. A significant percentage of these tumors present as metastatic disease of unknown primary site. The aim of this study was to better define the functional and clinical characteristics of carcinoids of unknown primary (CUP) site. Methods. This study examines the hormonal activity, clinical characteristics, and survival of 434 patients with carcinoids originating in the foregut, midgut, hindgut, or unknown location. The 143 patients with CUP were compared with the other groups with regard to presenting characteristics, diagnostic tests and therapeutic modalities used, hormonal activity, and survival. Results. The hormone levels (urinary 5-hydroxyindoleacetic acid and serotonin, serum and platelet serotonin) of CUP were not significantly different from midgut carcinoids with metastatic disease. Although survival with CUP was shorter than with carcinoids with identified primaries (10-year survivals of 22{\%} vs 62{\%}, 50{\%}, and 48{\%} for foregut, midgut, and hindgut, respectively), the survival curve for CUP was quite similar to that of patients with midgut carcinoids with distant disease (10-year survival of 22{\%} vs 28{\%}). Conclusions, CUP are similar to midgut carcinoids presenting with metastatic disease with regard to hormone production and survival. Like other carcinoids, CUP can be an indolent disease process with gradual progression over decades.",
author = "Kirshbom, {P. M.} and Kherani, {A. R.} and Onaitis, {M. W.} and Feldman, {J. M.} and Douglas Tyler and Ellison, {E. C.}",
year = "1998",
doi = "10.1067/msy.1998.93105",
language = "English (US)",
volume = "124",
pages = "1063--1070",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Carcinoids of unknown origin

T2 - Comparative analysis with foregut, midgut, and hindgut carcinoids

AU - Kirshbom, P. M.

AU - Kherani, A. R.

AU - Onaitis, M. W.

AU - Feldman, J. M.

AU - Tyler, Douglas

AU - Ellison, E. C.

PY - 1998

Y1 - 1998

N2 - Background. Carcinoids are rare neuroendocrine tumors typically arising in the gastrointestinal tract. A significant percentage of these tumors present as metastatic disease of unknown primary site. The aim of this study was to better define the functional and clinical characteristics of carcinoids of unknown primary (CUP) site. Methods. This study examines the hormonal activity, clinical characteristics, and survival of 434 patients with carcinoids originating in the foregut, midgut, hindgut, or unknown location. The 143 patients with CUP were compared with the other groups with regard to presenting characteristics, diagnostic tests and therapeutic modalities used, hormonal activity, and survival. Results. The hormone levels (urinary 5-hydroxyindoleacetic acid and serotonin, serum and platelet serotonin) of CUP were not significantly different from midgut carcinoids with metastatic disease. Although survival with CUP was shorter than with carcinoids with identified primaries (10-year survivals of 22% vs 62%, 50%, and 48% for foregut, midgut, and hindgut, respectively), the survival curve for CUP was quite similar to that of patients with midgut carcinoids with distant disease (10-year survival of 22% vs 28%). Conclusions, CUP are similar to midgut carcinoids presenting with metastatic disease with regard to hormone production and survival. Like other carcinoids, CUP can be an indolent disease process with gradual progression over decades.

AB - Background. Carcinoids are rare neuroendocrine tumors typically arising in the gastrointestinal tract. A significant percentage of these tumors present as metastatic disease of unknown primary site. The aim of this study was to better define the functional and clinical characteristics of carcinoids of unknown primary (CUP) site. Methods. This study examines the hormonal activity, clinical characteristics, and survival of 434 patients with carcinoids originating in the foregut, midgut, hindgut, or unknown location. The 143 patients with CUP were compared with the other groups with regard to presenting characteristics, diagnostic tests and therapeutic modalities used, hormonal activity, and survival. Results. The hormone levels (urinary 5-hydroxyindoleacetic acid and serotonin, serum and platelet serotonin) of CUP were not significantly different from midgut carcinoids with metastatic disease. Although survival with CUP was shorter than with carcinoids with identified primaries (10-year survivals of 22% vs 62%, 50%, and 48% for foregut, midgut, and hindgut, respectively), the survival curve for CUP was quite similar to that of patients with midgut carcinoids with distant disease (10-year survival of 22% vs 28%). Conclusions, CUP are similar to midgut carcinoids presenting with metastatic disease with regard to hormone production and survival. Like other carcinoids, CUP can be an indolent disease process with gradual progression over decades.

UR - http://www.scopus.com/inward/record.url?scp=0031731645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031731645&partnerID=8YFLogxK

U2 - 10.1067/msy.1998.93105

DO - 10.1067/msy.1998.93105

M3 - Article

VL - 124

SP - 1063

EP - 1070

JO - Surgery

JF - Surgery

SN - 0039-6060

IS - 6

ER -