Cardiac injury in patients with COPD presenting with dyspnea: a pilot study.

Esosa Odigie-Okon, Bryan Jordan, Sylvester Dijeh, Armand Wolff, Razvan Dadu, Priyanka Lall, Stuart Zarich, Yaw Amoateng-Adjepong, Constantine A. Manthous

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The aim of this pilot study was to test the hypothesis that myocardial ischemia complicates the management of some patients with chest-pain-free chronic obstructive pulmonary disease (COPD) exacerbations. In this prospective, observational, cohort study, patients admitted to a 350-bed community teaching hospital, with dyspnea and a primary diagnosis of COPD exacerbation, were followed for enzymatic and electrocardiographic evidence of myocardial ischemia for the first 24 hours of hospital admission. A total of 114 patients were studied. Overall, four patients had definite myocardial infarctions, one had definite myocardial ischemia and 14 had possible myocardial ischemia. In multiple logistic regression models, age, number of coronary risk factors, and amount of administered albuterol were not associated with myocardial injury. While unrecognized myocardial injury is relatively rare in patients with an exacerbation of COPD, it occurs frequently enough to warrant some caution since beta-agonists are the mainstays of therapy.

Original languageEnglish (US)
Pages (from-to)395-399
Number of pages5
JournalInternational Journal of COPD
Volume5
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

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