Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis

Medicine & Life Sciences

• Chagas Disease 97%
• 4-hydroxy-2-nonenal 61%
• Antigens 51%
• Antibodies 45%
• Cardiac Myocytes 32%
• Heart 30%
• Proteins 29%
• Reactive Oxygen Species 27%
• Western Blotting 23%
• Blood Proteins 20%
• Rodentia 19%
• phenyl-N-tert-butylnitrone 18%
• Connectin 16%
• 3-nitrotyrosine 14%
• Trypanosoma cruzi 14%
• Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry 13%
• Electrophoresis, Gel, Two-Dimensional 13%
• Malondialdehyde 11%
• Proteomics 10%
• Serum 10%
• In Vitro Techniques 10%
• Antioxidants 8%
• Enzyme-Linked Immunosorbent Assay 8%
• Pathology 7%
• Biopsy 7%
• Therapeutics 1%

Agriculture & Biology

• Chagas disease 100%
• pathogenesis 74%
• antigens 60%
• antibodies 53%
• cardiomyocytes 33%
• heart 28%
• proteins 27%
• rats 23%
• Western blotting 23%
• reactive oxygen species 22%
• rodents 15%
• oxidation 13%
• immunogenicity 10%
• matrix-assisted laser desorption-ionization mass spectrometry 10%
• mice 10%
• Trypanosoma cruzi 10%
• two-dimensional gel electrophoresis 9%
• lethal dose 50 9%
• tandem mass spectrometry 8%
• malondialdehyde 8%
• proteomics 8%
• immune response 7%
• enzyme-linked immunosorbent assay 7%
• antioxidants 5%

Chemical Compounds

• Antigen 68%
• Western Blotting 34%
• Protein 33%
• 3-Nitrotyrosine 13%
• Two Dimensional Polyacrylamide Gel Electrophoresis 10%
• Nitrone 10%
• Matrix Assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF) 10%
• Dioxygen 8%
• Reactive Oxygen Metabolite 8%
• Oxidation Reaction 8%
• Antioxidant Agent 6%
• Adduct 6%
• Modification 5%