Cardiac Preconditioning With Local Laser-Induced Hyperthermia

Bin Gong, Brent Bell, Paul J. Boor, Thomas B. Albrecht, Gregory K. Asimakis, Massoud Motamedi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Whole body hyperthermia has been shown to be highly effective in preconditioning cardiac tissue against reperfusion injury. The current study was aimed to assess the ability of regional sublethal laser-induced hyperthermia to precondition cardiac tissue against ischemic-induced myocardial infarction. Methods and results: Diode laser radiation was used to locally heat (42°C) the left ventricle by irradiating the epicardial surface of rat heart for 20 min. As control, another group of animals were treated with whole-body hyperthermia (WBH) for 20 min. After a 4-h recovery period, the left coronary artery was occluded for 30 min followed by 4 h of reperfusion. A significant degree of reduction in infarct size as assessed by percent of at-risk area was observed in animals that were subjected to laser-induced local hyperthermia (15.4 ± 3.1; n = 5) versus the sham group (49.8 ± 6.6; n = 5). The degree of cardiac protection induced by local hyperthermia was similar to the protection observed when the animals were preconditioned with WBH. Furthermore, regional laser-induced hyperthermia and WBH induced similar degree of up-regulation of heat shock protein 70 in cardiac tissue. Regional hyperthermia up-regulated heat shock protein in regions of the heart beyond that directly subjected to laser-induced heat stress. Conclusion: Sublethal local heating of the heart with diode laser irradiation can improve myocardial salvage and may provide a practical approach for tissue preconditioning against reperfusion injury.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalJournal of Surgical Research
Volume149
Issue number2
DOIs
StatePublished - Oct 2008

Fingerprint

Induced Hyperthermia
Lasers
Fever
Semiconductor Lasers
Reperfusion Injury
Hot Temperature
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Heating
Reperfusion
Heart Ventricles
Coronary Vessels
Up-Regulation
Myocardial Infarction
Radiation
Control Groups

Keywords

  • heart
  • heat shock protein 70
  • hyperthermia
  • ischemia
  • laser
  • precondition

ASJC Scopus subject areas

  • Surgery

Cite this

Cardiac Preconditioning With Local Laser-Induced Hyperthermia. / Gong, Bin; Bell, Brent; Boor, Paul J.; Albrecht, Thomas B.; Asimakis, Gregory K.; Motamedi, Massoud.

In: Journal of Surgical Research, Vol. 149, No. 2, 10.2008, p. 177-183.

Research output: Contribution to journalArticle

Gong, Bin ; Bell, Brent ; Boor, Paul J. ; Albrecht, Thomas B. ; Asimakis, Gregory K. ; Motamedi, Massoud. / Cardiac Preconditioning With Local Laser-Induced Hyperthermia. In: Journal of Surgical Research. 2008 ; Vol. 149, No. 2. pp. 177-183.
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