Cardiopulmonary reference standards in the pregnant sheep (Ovis aries): A comparative study of ovine and human physiology in obstetrics

John H. Cissik, William J. Ehler, Gary Hankins, Russell Snyder

Research output: Contribution to journalArticle

12 Scopus citations


1. 1. Complete blood counts, respiratory rate, tidal volume, arterial and mixed venous blood gases; heart rate, cardiac output, and arterial, pulmonary artery, central venous and pulmonary wedge pressures were determined in 10 pregnant adult sheep of 42.7-65.7 kg body weight. 2. 2. Arithmetic means, standard deviations, and coefficients of variation were calculated to develop reference values; in addition, the 95% confidence limits for ranges were established. 3. 3. Comparison of derived data with that from non-pregnant sheep shows changes similar to those seen when examining pregnant and non-pregnant humans. 4. 4. These results indicate the pregnant sheep is an acceptable model for human obstetrical research.

Original languageEnglish (US)
Pages (from-to)877-880
Number of pages4
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Issue number4
StatePublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Biochemistry

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