Cardiovascular distribution of the calcium sensing receptor before and after burns

Gordon L. Klein, Perenlei Enkhbaatar, Daniel L. Traber, L. Max Buja, Colette C. Jonkam, Brian J. Poindexter, Roger J. Bick

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Due to up-regulation of the parathyroid gland calcium-sensing receptor (CaR), burned children have hypocalcemic hypoparathyroidism, and decreased myocardial contractility. Our aim was to localize the CaR in the heart and measure receptor density changes due to burns. Heart and aorta samples from sheep subjected to 40% burn or sham conditions were probed for CaR via fluorescence microscopy. CaR was localized to endocardial endothelium, myocardial microvasculature, and fibroblasts and vessels of the aortic adventitia. CaR was not found in cardiomyocytes or smooth muscle cells. No differences in density of CaR or β-adrenergic receptors were noted. No differences in CaR distribution were seen in the myocardium or aorta, in contrast to the parathyroid where burn injury up-regulates CaR. We suggest that CaR has a local, tissue-specific role, and functions in vascular calcium sensing for intravascular calcium deposition or regulation of other calcium channels after trauma or burn.

Original languageEnglish (US)
Pages (from-to)370-375
Number of pages6
JournalBurns
Volume34
Issue number3
DOIs
StatePublished - May 2008

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Keywords

  • Aorta
  • Burns
  • Calcium sensing receptor
  • Fluorescence microscopy
  • Heart

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Klein, G. L., Enkhbaatar, P., Traber, D. L., Buja, L. M., Jonkam, C. C., Poindexter, B. J., & Bick, R. J. (2008). Cardiovascular distribution of the calcium sensing receptor before and after burns. Burns, 34(3), 370-375. https://doi.org/10.1016/j.burns.2007.04.010