Case-case analysis using 7 years of travelers' diarrhea surveillance data

Preventive and travel medicine applications in cusco, Peru

Mary Carol Jennings, Drake H. Tilley, Sarah Blythe Ballard, Miguel Villanueva, Fernando Maldonado Costa, Martha Lopez, Hannah E. Steinberg, C. Giannina Luna, Rina Meza, Maria E. Silva, Robert H. Gilman, Mark P. Simons, Ryan C. Maves, Miguel Cabada

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In Cusco, Peru, and South America in general, there is a dearth of travelers' diarrhea (TD) data concerning the clinical features associated with enteropathogen-specific infections and destination-specific risk behaviors. Understanding these factors would allow travel medicine providers to tailor interventions to patients' risk profiles and travel destination. To characterize TD etiology, evaluate region-specific TD risk factors, and examine relationships between preventive recommendations and risk-taking behaviors among medium- to long-term travelers' from high-income countries, we conducted this case-case analysis using 7 years of prospective surveillance data from adult travelers' presenting with TD to a physician in Cusco. At the time of enrollment, participants provided a stool sample and answered survey questions about demographics, risk behaviors, and the clinical features of illness. Stool samples were tested for norovirus (NV), bacteria, and parasites using conventional methods. Data obtained were then analyzed using case-case methods. NV (14%), enterotoxigenic Escherichia coli (11%), and Campylobacter (9%), notably ciprofloxacinresistant Campylobacter, were the most frequently identified pathogens among adults with TD. Coinfection with multiple enteropathogens occurred in 5% of cases. NV caused severe disease relative to other TD-associated pathogens identified, confining over 90% of infected individuals to bed. Destination-specific risk factors include consumption of the local beverage chicha, which was associated with Cryptosporidium infection. Preventive interventions, such as vaccines, directed against these pathogens could significantly reduce the burden of TD.

Original languageEnglish (US)
Pages (from-to)1097-1106
Number of pages10
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume96
Issue number5
DOIs
StatePublished - Jan 1 2017

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Travel Medicine
Preventive Medicine
Peru
Diarrhea
Norovirus
Risk-Taking
Campylobacter
Enterotoxigenic Escherichia coli
Cryptosporidium
South America
Beverages
Infection
Coinfection
Parasites
Vaccines
Demography
Bacteria
Physicians

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Case-case analysis using 7 years of travelers' diarrhea surveillance data : Preventive and travel medicine applications in cusco, Peru. / Jennings, Mary Carol; Tilley, Drake H.; Ballard, Sarah Blythe; Villanueva, Miguel; Costa, Fernando Maldonado; Lopez, Martha; Steinberg, Hannah E.; Luna, C. Giannina; Meza, Rina; Silva, Maria E.; Gilman, Robert H.; Simons, Mark P.; Maves, Ryan C.; Cabada, Miguel.

In: American Journal of Tropical Medicine and Hygiene, Vol. 96, No. 5, 01.01.2017, p. 1097-1106.

Research output: Contribution to journalArticle

Jennings, MC, Tilley, DH, Ballard, SB, Villanueva, M, Costa, FM, Lopez, M, Steinberg, HE, Luna, CG, Meza, R, Silva, ME, Gilman, RH, Simons, MP, Maves, RC & Cabada, M 2017, 'Case-case analysis using 7 years of travelers' diarrhea surveillance data: Preventive and travel medicine applications in cusco, Peru', American Journal of Tropical Medicine and Hygiene, vol. 96, no. 5, pp. 1097-1106. https://doi.org/10.4269/ajtmh.16-0633
Jennings, Mary Carol ; Tilley, Drake H. ; Ballard, Sarah Blythe ; Villanueva, Miguel ; Costa, Fernando Maldonado ; Lopez, Martha ; Steinberg, Hannah E. ; Luna, C. Giannina ; Meza, Rina ; Silva, Maria E. ; Gilman, Robert H. ; Simons, Mark P. ; Maves, Ryan C. ; Cabada, Miguel. / Case-case analysis using 7 years of travelers' diarrhea surveillance data : Preventive and travel medicine applications in cusco, Peru. In: American Journal of Tropical Medicine and Hygiene. 2017 ; Vol. 96, No. 5. pp. 1097-1106.
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