Case-matching analysis of head and neck squamous cell carcinoma in racial and ethnic minorities in the United States-Possible role for human papillomavirus in survival disparities

Travis P. Schrank, Yimei Han, Heidi Weiss, Vicente Resto

Research output: Contribution to journalArticle

39 Scopus citations


Background. Several studies have documented disparities in head and neck cancer outcomes for black patients in the United States. Recent studies have found that differences in oropharyngeal tumor human papillomavirus (HPV) status may be a cause of this disparity. Methods. In all, 76,817 cases of head and neck squamous cell carcinoma (HNSCC) recorded in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program were analyzed. Racial/ethnic groups were studied, for disease-specific survival in both case-matched and nonmatched cohorts. Calculation of expected disparity magnitudes based on HPV status was performed using data reported in the literature. Results. A disease-specific survival disparity was demonstrated for Hispanic patients. However, case matching eliminated this disparity. Conversely, the disparity for black patients persisted in matched cohorts. The oropharyngeal subsite was found to be the dominant contributor to this disparity. Conclusions. The survival disparity for Hispanic patients in SEER with HNSCC is explained by differences in presentation and treatment. Also, HPV tumor status is likely a key determinant of the disparity for black patients.

Original languageEnglish (US)
Pages (from-to)45-53
Number of pages9
JournalHead and Neck
Issue number1
StatePublished - Jan 2011



  • disparities
  • head and neck squamous cell carcinoma
  • human papillomavirus
  • race
  • survival

ASJC Scopus subject areas

  • Otorhinolaryngology

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