@article{77bc42e0534d4d5bbd4ba92030148c1e,
title = "Case study of two post vaccination SARS-CoV-2 infections with P1 variants in coronavac vaccinees in Brazil",
abstract = "The rapid development of efficacious and safe vaccines against coronavirus disease 2019 (COVID-19) has been instrumental in mitigating the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, the emergence of SARS-CoV-2 variants raised concerns on the efficacy of these vaccines. Herein, we report two cases of breakthrough infections with the P1 variant in patients vaccinated with CoronaVac, which is one of the two vaccines authorized for emergency use in the Brazilian immunization program. Our observations suggest that the vaccine reduced the severity of the disease and highlight the potential risk of illness following vaccination and subsequent infection with the P1 variant as well as for continued efforts to prevent and diagnose infection in vaccinated persons.",
keywords = "COVID-19, SARS-CoV-2, Vaccine",
author = "Estofolete, {Cassia F.} and Banho, {Cecilia A.} and Campos, {Guilherme R.F.} and Marques, {Beatriz C.} and Livia Sacchetto and Ullmann, {Leila S.} and Possebon, {Fabio S.} and Machado, {Luana F.} and Syrio, {Juliana D.} and {Ara{\'u}jo Junior}, {Jo{\~a}o P.} and Cintia Bittar and Paula Rahal and Lobo, {Suzana M.A.} and Ferreira, {Helena Lage} and Nikos Vasilakis and Nogueira, {Mauricio L.}",
note = "Funding Information: Funding: This work is supported by the FAPESP-COVID Program (Grant # 2020/04836-0 to MLN) and partly by a Centers for Research in Emerging Infectious Diseases (CREID) 1U01AI151807 grant awarded to NV by the National Institutes of Health (NIH). MLN is supported by FAPESP (Grant # 2013/21719/3). JPAJ and MLN are CNPq Research Fellows. The funders had no role in the design of the study, collection, analyses, or interpretation of data, writing of the manuscript, or in the decision to publish the results. Funding Information: This work is supported by the FAPESP-COVID Program (Grant # 2020/04836-0 to MLN) and partly by a Centers for Research in Emerging Infectious Diseases (CREID) 1U01AI151807 grant awarded to NV by the National Institutes of Health (NIH). MLN is supported by FAPESP (Grant # 2013/21719/3). JPAJ and MLN are CNPq Research Fellows. The funders had no role in the design of the study, collection, analyses, or interpretation of data, writing of the manuscript, or in the decision to publish the results. Publisher Copyright: {\textcopyright} 2021 by the authors.",
year = "2021",
month = jul,
doi = "10.3390/v13071237",
language = "English (US)",
volume = "13",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",
}