Cassia cinnamon for the attenuation of glucose intolerance and insulin resistance resulting from sleep loss

Jean Jitomir, Darryn S. Willoughby

    Research output: Contribution to journalArticlepeer-review

    14 Scopus citations

    Abstract

    Epidemiological investigations reveal a concomitant increase in sleep loss and metabolic diseases, including type 2 diabetes mellitus, over the past several decades. An increasing body of scientific evidence indicates that acute sleep loss induces insulin resistance and glucose intolerance profiles similar to those of type 2 diabetes mellitus patients. Experimentally, cassia cinnamon (Cinnamomum cassia) supplementation facilitates glucose disposal in healthy humans, which may be achieved by enhancing (1) insulin sensitivity via increased phosphorylation of signaling proteins and (2) insulin-sensitive glucose transporter 4-mediated glucose uptake into muscle cells. Because peripheral insulin resistance is primarily a consequence of reduced muscle insulin sensitivity, C. cassia and C. cassia extracts may attenuate insulin resistance and glucose intolerance observed following sleep loss.

    Original languageEnglish (US)
    Pages (from-to)467-472
    Number of pages6
    JournalJournal of Medicinal Food
    Volume12
    Issue number3
    DOIs
    StatePublished - Jun 1 2009

    Keywords

    • Diabetes
    • Fructose
    • Insulin signaling
    • Medicinal plant
    • Sleep deprivation

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

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