Catabolic hormones alone fail to reproduce the stress-induced efflux of amino acids

J. A. Brown, Dennis Gore, F. Jahoor

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To determine the impact of catabolic hormones on the pattern of amino acid efflux from human skeletal muscle during stress. Design: Cohort analytical study. Setting: Burn intensive care unit and clinical research facility at a university hospital. Patients: Five patients with severe burns and five healthy volunteers of similar size and age. Interventions and Measurements: The net balance of amino acids across the leg was determined in five healthy volunteers prior to and following a 2-hour infusion of the catabolic hormones epinephrine, cortisol, and glucagon into the femoral artery. These results were compared with amino acid net balance measurements in five severely burned patients. Results: Hormonal simulation of stress in the normal volunteers increased glutamine efflux from the leg to an extent similar to that of the burn patients. Alanine efflux, however, was not affected by the hormonal infusion. Because alanine efflux constituted a major proportion of the total peripheral amino acid catabolism in the burn patients, there was significantly less total amino acid nitrogen loss from the healthy volunteers receiving the stress hormones. Conclusions: Catabolic hormones alone fail to reproduce the stress-induced pattern and quantity of amino acid efflux from human skeletal muscle. This discrepancy is largely due to an unresponsiveness of alanine to hormonally induced muscle protein catabolism.

Original languageEnglish (US)
Pages (from-to)819-824
Number of pages6
JournalArchives of Surgery
Volume129
Issue number8
StatePublished - 1994
Externally publishedYes

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Hormones
Amino Acids
Healthy Volunteers
Alanine
Leg
Skeletal Muscle
Muscle Proteins
Femoral Artery
Glucagon
Glutamine
Burns
Epinephrine
Intensive Care Units
Hydrocortisone
Cohort Studies
Nitrogen
Research

ASJC Scopus subject areas

  • Surgery

Cite this

Catabolic hormones alone fail to reproduce the stress-induced efflux of amino acids. / Brown, J. A.; Gore, Dennis; Jahoor, F.

In: Archives of Surgery, Vol. 129, No. 8, 1994, p. 819-824.

Research output: Contribution to journalArticle

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